Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Nov 29;72(1).
doi: 10.2478/aite-2024-0024. eCollection 2024 Jan 1.

Asymptomatic Hyperuricemia: A Nephro-Rheumatological Perspective

Barbara Moszczuk  1 , Katarzyna Życińska  2   3 , Krzysztof Mucha  4   5
Affiliations
Free article
Review

Asymptomatic Hyperuricemia: A Nephro-Rheumatological Perspective

Barbara Moszczuk et al. Arch Immunol Ther Exp (Warsz). .
Free article

Abstract

Hyperuricemia (HU) is a common disorder associated with gout, kidney injury, and high cardiovascular risk. However, whether high serum uric acid (sUA) is a causative factor or just comorbidity remains unclear. When asked if asymptomatic hyperuricemic patients need treatment, even artificial intelligence in the form of the GPT chat provides an ambivalent answer and refers us to a healthcare provider. We believe that such discrepancies stem from an incomplete understanding of the role that uric acid (UA) plays inside and outside the cell. With the rapid development of genomics, proteomics, immunology, and novel biomarkers, we are armed with new data to help us better understand the weight of inborn and environmental factors on an individual's UA concentrations. This review sums up the latest progress that has been made in the field of asymptomatic HU, compares the results presented by various research teams, and indicates new directions that emerge for future studies.

Keywords: Asymptomatic; Chronic kidney disease; Hyperuricemia; Uric acid lowering therapy.

PubMed Disclaimer

References

    1. Ayoub I, Almaani S, Brodsky S et al. (2016) Revisiting medullary tophi: A link between uric acid and progressive chronic kidney disease? Clin Nephrol 85:109–113. https://doi.org/10.5414/CN108663
    1. Baek CH, Kim H, Yang WS et al. (2018) Efficacy and safety of febuxostat in kidney transplant patients. Exp Clin Transplant 16:401–406. https://doi.org/10.6002/ECT.2016.0367
    1. Bardin T, Nguyen QD, Tran KM et al. (2021) A cross-sectional study of 502 patients found a diffuse hyperechoic kidney medulla pattern in patients with severe gout. Kidney Int 99:218–226. https://doi.org/10.1016/J.KINT.2020.08.024
    1. Chen CJ, Tseng CC, Yen JH et al. (2018) ABCG2 contributes to the development of gout and hyperuricemia in a genome-wide association study. Sci Rep 8:3137. https://doi.org/10.1038/s41598-018-21425-7
    1. Chen MY, Wang AP, Wang JW et al. (2019) Coexistence of hyperuricaemia and low urinary uric acid excretion further increases risk of chronic kidney disease in type 2 diabetes. Diabetes Metab 45:557–563. https://doi.org/10.1016/J.DIABET.2019.03.001

LinkOut - more resources