Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Feb;32(1):59-64.
doi: 10.1007/s10140-024-02298-y. Epub 2024 Nov 30.

Diagnostic performance of ChatGPT in tibial plateau fracture in knee X-ray

Affiliations

Diagnostic performance of ChatGPT in tibial plateau fracture in knee X-ray

Mohammadreza Mohammadi et al. Emerg Radiol. 2025 Feb.

Abstract

Purpose: Tibial plateau fractures are relatively common and require accurate diagnosis. Chat Generative Pre-Trained Transformer (ChatGPT) has emerged as a tool to improve medical diagnosis. This study aims to investigate the accuracy of this tool in diagnosing tibial plateau fractures.

Methods: A secondary analysis was performed on 111 knee radiographs from emergency department patients, with 29 confirmed fractures by computed tomography (CT) imaging. The X-rays were reviewed by a board-certified emergency physician (EP) and radiologist and then analyzed by ChatGPT-4 and ChatGPT-4o. The diagnostic performances were compared using the area under the receiver operating characteristic curve (AUC). Sensitivity, specificity, and likelihood ratios were also calculated.

Results: The results indicated a sensitivity and negative likelihood ratio of 58.6% (95% CI: 38.9 - 76.4%) and 0.4 (95% CI: 0.3-0.7) for the EP, 72.4% (95% CI: 52.7 - 87.2%) and 0.3 (95% CI: 0.2-0.6) for the radiologist, 27.5% (95% CI: 12.7 - 47.2%) and 0.7 (95% CI: 0.6-0.9) for ChatGPT-4, and 55.1% (95% CI: 35.6 - 73.5%) and 0.4 (95% CI: 0.3-0.7) for ChatGPT4o. The specificity and positive likelihood ratio were 85.3% (95% CI: 75.8 - 92.2%) and 4.0 (95% CI: 2.1-7.3) for the EP, 76.8% (95% CI: 66.2 - 85.4%) and 3.1 (95% CI: 1.9-4.9) for the radiologist, 95.1% (95% CI: 87.9 - 98.6%) and 5.6 (95% CI: 1.8-17.3) for ChatGPT-4, and 93.9% (95% CI: 86.3 - 97.9%) and 9.0 (95% CI: 3.6-22.4) for ChatGPT4o. The area under the receiver operating characteristic curve (AUC) was 0.72 (95% CI: 0.6-0.8) for the EP, 0.75 (95% CI: 0.6-0.8) for the radiologist, 0.61 (95% CI: 0.4-0.7) for ChatGPT-4, and 0.74 (95% CI: 0.6-0.8) for ChatGPT4-o. The EP and radiologist significantly outperformed ChatGPT-4 (P value = 0.02 and 0.01, respectively), whereas there was no significant difference between the EP, ChatGPT-4o, and radiologist.

Conclusion: ChatGPT-4o matched the physicians' performance and also had the highest specificity. Similar to the physicians, ChatGPT chatbots were not suitable for ruling out the fracture.

Keywords: Artificial intelligence; ChatGPT; Diagnosis; Emergency medicine; Radiology; Tibial plateau fracture.

PubMed Disclaimer

Conflict of interest statement

Declarations. Ethics approval and consent to participate: The study was approved by the institutional ethical review board at the university and conducted following the Declaration of Helsinki. Competing interests: The authors declare no competing interests.

References

    1. Herteleer M, Van Brandt C, Vandoren C, Nijs S, Hoekstra H (2022) Tibial plateau fractures in Belgium: epidemiology, financial burden and costs curbing strategies. Eur J Trauma Emerg Surg 48(5):3643–3650 - DOI - PubMed
    1. Bormann M, Neidlein C, Gassner C, Keppler AM, Bogner-Flatz V, Ehrnthaller C et al (2023) Changing patterns in the epidemiology of tibial plateau fractures: a 10-year review at a level-I trauma center. Eur J Trauma Emerg Surg 49(1):401–409 - DOI - PubMed
    1. Ramponi DR, McSwigan T (2018) Tibial Plateau fractures. Adv Emerg Nurs J 40(3):155–161 - DOI - PubMed
    1. Rudran B, Little C, Wiik A, Logishetty K (2020) Tibial Plateau fracture: anatomy, diagnosis and management. Br J Hosp Med (Lond) 81(10):1–9 - DOI - PubMed
    1. Schatzker J, Kfuri M (2022) Revisiting the management of tibial plateau fractures. Injury 53(6):2207–2218 - DOI - PubMed