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Review
. 2025 Feb;44(5):277-287.
doi: 10.1038/s41388-024-03221-y. Epub 2024 Nov 29.

Emerging roles of cohesin-STAG2 in cancer

Julia S Scott #  1 , Loubna Al Ayadi #  1 , Emmanouela Epeslidou  1 , Roan H van Scheppingen  1 , Anna Mukha  2 , Lucas J T Kaaij  1 , Catrin Lutz  3   4 , Stefan Prekovic  5
Affiliations
Review

Emerging roles of cohesin-STAG2 in cancer

Julia S Scott et al. Oncogene. 2025 Feb.

Erratum in

  • Correction: Emerging roles of cohesin-STAG2 in cancer.
    Scott JS, Al Ayadi L, Epeslidou E, van Scheppingen RH, Mukha A, Kaaij LJT, Lutz C, Prekovic S. Scott JS, et al. Oncogene. 2025 Aug;44(29):2561-2562. doi: 10.1038/s41388-025-03479-w. Oncogene. 2025. PMID: 40542201 No abstract available.

Abstract

Cohesin, a crucial regulator of genome organisation, plays a fundamental role in maintaining chromatin architecture as well as gene expression. Among its subunits, STAG2 stands out because of its frequent deleterious mutations in various cancer types, such as bladder cancer and melanoma. Loss of STAG2 function leads to significant alterations in chromatin structure, disrupts transcriptional regulation, and impairs DNA repair pathways. In this review, we explore the molecular mechanisms underlying cohesin-STAG2 function, highlighting its roles in healthy cells and its contributions to cancer biology, showing how STAG2 dysfunction promotes tumourigenesis and presents opportunities for targeted therapeutic interventions.

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Conflict of interest statement

Competing interests: The authors declare no competing interests.

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