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. 2024 Nov 29;13(1):57.
doi: 10.1186/s40035-024-00451-8.

Aquaporin-4 as a cerebrospinal fluid biomarker of Alzheimer's disease

Nerea Gómez de San José #  1 , Steffen Halbgebauer #  1   2 , Petra Steinacker  3 , Sarah Anderl-Straub  1 , Samir Abu-Rumeileh  3 , Lorenzo Barba  3 , Patrick Oeckl  1   2 , Giovanni Bellomo  4 , Lorenzo Gaetani  4 , Andrea Toja  4 , Sára Mravinacová  5 , Sofia Bergström  5 , Anna Månberg  5 , Alberto Grassini  6 , Innocenzo Rainero  6 , Peter Nilsson  5 , Lucilla Parnetti  4 , Markus Otto  7
Affiliations

Aquaporin-4 as a cerebrospinal fluid biomarker of Alzheimer's disease

Nerea Gómez de San José et al. Transl Neurodegener. .
No abstract available

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: The studies obtained approval from respective ethics committees (Ulm University Hospital, No. 20/10; University Perugia, 19369/08/AV registry no: 1287/08 date: 9 October 2008 and University of Turin, 0114576) and adhered to the most recent iteration of the Declaration of Helsinki. Prior to participation, all the participants or their caregivers received a thorough explanation of the study's procedures and gave written consent. Consent for publication: Not applicable. Competing interests: Dr. Gaetani participated on advisory boards for, and received writing honoraria and travel grants from Almirall, Biogen, Euroimmun, Fujirebio, Lilly, Merck, Mylan, Novartis, Roche, Sanofi, Siemens Healthineers and Teva.

Figures

Fig. 1
Fig. 1
Aquaporin 4 (AQP4) CSF analysis in three different cohorts. CSF AQP4 in the discovery cohort (n = 157) including 38 CON, 40 AD, 21 PPA, 20 bvFTD, 17 ALS and 21 LBD (a, b) and in the validation cohorts I and II: cohort I (n = 108) including 37 CON, 14 preAD, 28 AD-MCI and 29 ADD (c, d) and cohort II (n = 68) including 18 CON, 23 AD-MCI, 10 ADD and 17 non-AD MCI (e, f). Boxplots represent median, Q1 and Q3 quartiles, and whiskers from minimum to maximum. *P < 0.05, **P < 0.01, and ***P < 0.001. b, d, f Receiver operating characteristics curve analysis of CSF AQP4. AD, Alzheimer’s disease; ALS; amyotrophic lateral sclerosis; AUC, area under the curve; bvFTD, behavioral variant frontotemporal dementia; CON, control; CSF, cerebrospinal fluid; IQR, interquartile range; LBD, Lewy body disease; PPA, primary progressive aphasia
See this image and copyright information in PMC

References

    1. Blennow K, Zetterberg H. Biomarkers for Alzheimer’s disease: current status and prospects for the future. J Intern Med. 2018;284(6):643–63. - DOI - PubMed
    1. Zenaro E, Piacentino G, Constantin G. The blood-brain barrier in Alzheimer’s disease. Neurobiol Dis. 2017;107:41–56. - DOI - PMC - PubMed
    1. Wildsmith KR, Holley M, Savage JC, Skerrett R, Landreth GE. Evidence for impaired amyloid beta clearance in Alzheimer’s disease. Alzheimers Res Ther. 2013;5(4):33. - DOI - PMC - PubMed
    1. Nielsen S, Nagelhus EA, Amiry-Moghaddam M, Bourque C, Agre P, Ottersen OP. Specialized membrane domains for water transport in glial cells: high-resolution immunogold cytochemistry of aquaporin-4 in rat brain. J Neurosci. 1997;17(1):171–80. - DOI - PMC - PubMed
    1. Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta. Sci Transl Med. 2012;4(147):147ra111. - DOI - PMC - PubMed

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