Fostering healthy cognitive ageing in people living with HIV

Lucette A Cysique¹, Jules Levin², Chris Howard³, Jeff Taylor⁴, John Rule⁵, Jane Costello⁶, Jane Bruning⁷, Priscilla Njeri⁶, Amy B Mullens⁸, Edwina Wright⁹, Hetta Gouse¹⁰, Kirstie Daken⁸, Mattia Trunfio¹¹, Htein Linn Aung¹², Reuben N Robbins¹³, Christopher M Ferraris¹³, Jose A Muñoz-Moreno¹⁴, Steven P Woods¹⁵, David J Moore¹⁶, Christopher Power¹⁷, Pui Li Wong¹⁸, Kejal Hasmukharay¹⁹, Primrose Nyamayaro²⁰, Jaime Vera²¹, Reena Rajasuriar¹⁸, Robert K Heaton¹⁶, Karl Goodkin²², Scott Letendre¹⁶, Ronald J Ellis¹⁶, Bruce J Brew²³, Sean B Rourke²⁴; NeuroHIV and Aging Advocacy Group

Affiliations

¹ MAP Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada; Peter Duncan Neuroscience Research Unit, St Vincent's Centre for Applied Medical Research, Darlinghurst, NSW, Australia; School of Psychology, University of New South Wales, Sydney, NSW, Australia; The Kirby Institute, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia. Electronic address: lcysique@unsw.edu.au.
² National AIDS Treatment Advocacy Project, New York, NY, USA.
³ Queensland Positive People, Brisbane, QLD, Australia.
⁴ HIV+Aging Research Project-Palm Springs, Palm Springs, CA, USA.
⁵ National Association of People with HIV Australia, Newtown, NSW, Australia.
⁶ Positive Life New South Wales, Surry Hills, NSW, Australia.
⁷ Positive Women, Auckland, Aotearoa New Zealand.
⁸ School of Psychology & Wellbeing, Centre for Health Research, Institute for Resilient Regions, University of Southern Queensland, Brisbane, QLD, Australia.
⁹ Department of Infectious Disease, Alfred Health, Melbourne, VIC, Australia; Burnet Institute, Melbourne, VIC, Australia; Department of Infectious Diseases, Monash University, Melbourne, VIC, Australia; The Peter Doherty Institute of Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia.
¹⁰ Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
¹¹ Department of Psychiatry, University of California San Diego, San Diego, CA, USA; Department of Medical Sciences, University of Turin, Turin, Italy.
¹² The Kirby Institute, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
¹³ HIV Center for Clinical and Behavioral Studies, Columbia University and the New York State Psychiatric Institute, New York, NY, USA.
¹⁴ Fight Infections Foundation, Infectious Diseases Department, Germans Trias Hospital, Barcelona, Spain; Faculty of Psychology and Education Sciences, Open University of Catalonia, Barcelona, Spain.
¹⁵ Department of Psychology, University of Houston, Houston, TX, USA.
¹⁶ Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
¹⁷ Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada.
¹⁸ Department of Medicine and Centre of Excellence for Research in AIDS, University Malaya, Kuala Lumpur, Malaysia.
¹⁹ Geriatric Unit, Department of Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
²⁰ Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
²¹ Department of Global Health and Infection, Brighton and Sussex Medical School, Brighton, UK.
²² Department of Psychiatry, University of Texas Rio Grande Valley, Harlingen, TX, USA.
²³ Peter Duncan Neuroscience Research Unit, St Vincent's Centre for Applied Medical Research, Darlinghurst, NSW, Australia; Department of Neurology and Department of Immunology, St Vincent's Hospital, Darlinghurst, NSW, Australia; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
²⁴ MAP Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

PMID: 39615509
DOI: 10.1016/S2352-3018(24)00248-0

Guideline

Fostering healthy cognitive ageing in people living with HIV

Lucette A Cysique et al. Lancet HIV. 2025 Jan.

. 2025 Jan;12(1):e71-e80.

doi: 10.1016/S2352-3018(24)00248-0. Epub 2024 Nov 29.

Authors

Affiliations

¹ MAP Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada; Peter Duncan Neuroscience Research Unit, St Vincent's Centre for Applied Medical Research, Darlinghurst, NSW, Australia; School of Psychology, University of New South Wales, Sydney, NSW, Australia; The Kirby Institute, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia. Electronic address: lcysique@unsw.edu.au.
² National AIDS Treatment Advocacy Project, New York, NY, USA.
³ Queensland Positive People, Brisbane, QLD, Australia.
⁴ HIV+Aging Research Project-Palm Springs, Palm Springs, CA, USA.
⁵ National Association of People with HIV Australia, Newtown, NSW, Australia.
⁶ Positive Life New South Wales, Surry Hills, NSW, Australia.
⁷ Positive Women, Auckland, Aotearoa New Zealand.
⁸ School of Psychology & Wellbeing, Centre for Health Research, Institute for Resilient Regions, University of Southern Queensland, Brisbane, QLD, Australia.
⁹ Department of Infectious Disease, Alfred Health, Melbourne, VIC, Australia; Burnet Institute, Melbourne, VIC, Australia; Department of Infectious Diseases, Monash University, Melbourne, VIC, Australia; The Peter Doherty Institute of Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia.
¹⁰ Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
¹¹ Department of Psychiatry, University of California San Diego, San Diego, CA, USA; Department of Medical Sciences, University of Turin, Turin, Italy.
¹² The Kirby Institute, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
¹³ HIV Center for Clinical and Behavioral Studies, Columbia University and the New York State Psychiatric Institute, New York, NY, USA.
¹⁴ Fight Infections Foundation, Infectious Diseases Department, Germans Trias Hospital, Barcelona, Spain; Faculty of Psychology and Education Sciences, Open University of Catalonia, Barcelona, Spain.
¹⁵ Department of Psychology, University of Houston, Houston, TX, USA.
¹⁶ Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
¹⁷ Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada.
¹⁸ Department of Medicine and Centre of Excellence for Research in AIDS, University Malaya, Kuala Lumpur, Malaysia.
¹⁹ Geriatric Unit, Department of Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
²⁰ Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
²¹ Department of Global Health and Infection, Brighton and Sussex Medical School, Brighton, UK.
²² Department of Psychiatry, University of Texas Rio Grande Valley, Harlingen, TX, USA.
²³ Peter Duncan Neuroscience Research Unit, St Vincent's Centre for Applied Medical Research, Darlinghurst, NSW, Australia; Department of Neurology and Department of Immunology, St Vincent's Hospital, Darlinghurst, NSW, Australia; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
²⁴ MAP Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

PMID: 39615509
DOI: 10.1016/S2352-3018(24)00248-0

Abstract

Prevalence and incidence of HIV among people aged 50 years and older continue to rise worldwide, generating increasing awareness among care providers, scientists, and the HIV community about the importance of brain health in older adults with HIV. Many age-related factors that adversely affect brain health can occur earlier and more often among people with HIV, including epigenetic ageing, chronic medical conditions (eg, cardiovascular disease), and age-related syndromes (eg, frailty). Extensive dialogue between HIV community leaders, health-care providers, and scientists has led to the development of a multidimensional response strategy to protect and enhance brain health in people ageing with HIV that spans across public health, clinical spaces, and research spaces. This response strategy was informed by integrated ageing care frameworks and is centred on prevention, early detection, and management of brain health issues associated with HIV (eg, neurocognitive disorders), with specific considerations for low-resource or middle-resource countries. A collaborative, international, and data-informed update of the diagnostic criteria for HIV-associated neurocognitive disorders is a cornerstone of the proposed response strategy. The proposed response strategy includes a dynamic, international, online knowledge hub that will provide a crucial community resource for emerging evidence on the brain health of people ageing with HIV.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests BJB reports royalties from Oxford University Press and Cambridge University Press; honoraria for presentations sponsored by the Neurological Association of South Africa, Jansen, and Biogen; patents (monoclonal antibody for quinolinic acid as part of test kit for monitoring multiple sclerosis severity and progression [PCT/IB2013/055902; patent office Australia], 2010; method and prognostic kit for monitoring multiple sclerosis [WO/2015/008111], 2013; and automatic fall and seizure detector [application number 2016904045 IP Australia Batch Reference SPBI-0001069085 by My Medic Watch]); a position as Chairperson of the data monitoring and ethics committee for the Lighthouse 2 phase 3 study of the antiretroviral Triumeq in Amyotrophic Lateral Sclerosis (King's College London, UK, and Tysabri Advisory Board Australia); and a role as a past President of the International Society for Neurovirology (2019–23). JV reports honoraria for presentations and research grants in trials sponsored by Merck, Janssen Cilag, ViiV Healthcare, and Gilead Sciences. KG reports support from the Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections (ACGT) Network (funded by the US National Institutes of Health) as Protocol Director for ACTG trial A5402, Cipla, and Dr Reddy's Laboratories. All other authors declare no competing interests.

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Grants and funding

R21 TW012370/TW/FIC NIH HHS/United States

LinkOut - more resources

Full Text Sources
- ClinicalKey
- Elsevier Science
Medical
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Fostering healthy cognitive ageing in people living with HIV

Affiliations

Fostering healthy cognitive ageing in people living with HIV

Authors

Affiliations

Abstract

Conflict of interest statement

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical