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. 2024 Nov;66(11):1967-1978.
doi: 10.1007/s00234-024-03459-z. Epub 2024 Dec 1.

Disturbed neurovascular coupling in patients with white matter hyperintensities: potential biomarker for cognitive impairment

Hui Li #  1   2 , Chao Chai #  3 , Yuanliang Xie  2 , Huiying Wang  3 , Xuedong Bai  4 , You Li  2 , Qin Zhong  2 , Mingze Xu  5 , Xiang Wang  6 , Shuang Xia  7
Affiliations

Disturbed neurovascular coupling in patients with white matter hyperintensities: potential biomarker for cognitive impairment

Hui Li et al. Neuroradiology. 2024 Nov.

Abstract

Purpose: To explore the neurovascular mechanisms of white matter hyperintensities (WMHs)-related cognitive impairment by introducing a neurovascular biomarker, neurovascular coupling (NVC).

Methods: We applied resting-state functional magnetic resonance imaging combined with arterial spin labeling to investigate the NVC dysfunctional patterns in patients with pure WMHs. Partial correlation, mediation, and exploratory subgroup analyses were adopted to explore the relationship among WMHs, NVC dysfunction, and cognitive decline.

Results: We found 21 brain regions with NVC dysfunction in patients with pure WMHs, mainly distributed in the default mode network, dorsal attention network, subcortical nucleus, and limbic system (p < 0.0125, Bonferroni correction). The NVC dysfunction of brain regions in the subcortical nucleus and limbic system correlated with the total WMHs burden and paraventricular WMHs burden (q < 0.05, FDR correction). The reduced NVC of the left amygdala partially mediated the impact of paraventricular WMHs on executive function (Mediation effect: -0.117; 95%CI: -4.042,-0.011; p < 0.05). Among the WMHs subjects without cognitive impairment, the increased NVC of the left basal ganglia significantly correlated with the MoCA score (r = 0.539, p < 0.05).

Conclusion: These findings reveal an underlying neurovascular mechanism of WMHs-related cognitive impairment. The neurovascular functions of the left amygdala and left basal ganglia may involve cognitive damage and compensation, respectively, and can be used as potential biomarkers and therapeutic targets for cognitive impairment in patients with WMHs.

Keywords: Arterial spin labeling; Cognitive impairment; Functional magnetic resonance imaging; Neurovascular coupling; White matter hyperintensities.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Central Hospital of Wuhan (WHZXKYL2022-183). Informed consent was obtained from all individual participants included in the study. Conflict of interest: We declare that we have no conflict of interest.

References

    1. Georgakis MK, Duering M, Wardlaw JM et al (2019) WMH and long-term outcomes in ischemic stroke: a systematic review and meta-analysis. Neurology 92:e1298–e1308. https://doi.org/10.1212/wnl.0000000000007142 - DOI - PubMed
    1. Pantoni L (2010) Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol 9:689–701. https://doi.org/10.1016/s1474-4422(10)70104-6 - DOI - PubMed
    1. de Leeuw FE, de Groot JC, Oudkerk M et al (2002) Hypertension and cerebral white matter lesions in a prospective cohort study. Brain 125:765–772. https://doi.org/10.1093/brain/awf077 - DOI - PubMed
    1. Debette S, Markus HS (2010) The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis. BMJ 341:c3666. https://doi.org/10.1136/bmj.c3666 - DOI - PubMed - PMC
    1. Hu HY, Ou YN, Shen XN et al (2021) White matter hyperintensities and risks of cognitive impairment and dementia: a systematic review and meta-analysis of 36 prospective studies. Neurosci Biobehav Rev 120:16–27. https://doi.org/10.1016/j.neubiorev.2020.11.007 - DOI - PubMed

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