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Review
. 2025;18(1):1-19.
doi: 10.1159/000542789. Epub 2024 Nov 30.

Guidance and Position of RINN22 regarding Precision Nutrition and Nutriomics

Omar Ramos-Lopez  1 , Taís Silveira Assmann  2 , Elcy Yaned Astudillo Muñoz  3 , Luis Baquerizo-Sedano  4 , Elisa Barrón-Cabrera  5 , Claudio Adrián Bernal  6 , Josefina Bressan  7 , Amanda Cuevas-Sierra  8 , Alberto Dávalos  9   10 , Ulises De la Cruz-Mosso  11 , Ana Laura De la Garza  12 , Daniel A De Luis  13 , Rocío I Díaz de la Garza  14 , Karina Dos Santos  15 , Roxana Carla Fernández-Condori  16 , Alfredo Fernández-Quintela  17   18 , Diego F Garcia Diaz  19 , Karina Gonzalez-Becerra  20 , Eliane Lopes Rosado  21 , María-Carmen López de Las Hazas  10 , Bertha Araceli Marín Alejandre  22 , Alberto Angel Martin  23 , Erika Martinez-Lopez  24 , Diego Martínez-Urbistondo  25 , Fermin I Milagro  9   26 , Helen Hermana M Hermsdorff  7 , Begoña Muguerza  27 , Carolina F Nicoletti  28 , Ana Maria Obregón Rivas  29 , Isela Parra-Rojas  30 , Maria Puy Portillo  31   18 , José L Santos  32 , Thais Steemburgo  33 , Maria Elizabeth Tejero  34 , Anny Cristina Terán  35 , Victor Treviño  36 , Bárbara Vizmanos  37 , J Alfredo Martinez  38   9   39
Affiliations
Review

Guidance and Position of RINN22 regarding Precision Nutrition and Nutriomics

Omar Ramos-Lopez et al. Lifestyle Genom. 2025.

Abstract

Background: Precision nutrition is based on the integration of individual's phenotypical and biological characteristics including genetic variants, epigenetic marks, gut microbiota profiles, and metabolite fingerprints as well as medical history, lifestyle practices, and environmental and cultural factors. Thus, nutriomics areas including nutrigenomics, nutrigenetics, nutriepigenetics, nutrimetabolomics, and nutrimetagenomics have emerged to comprehensively understand the complex interactions between nutrients, diet, and the human body's molecular processes through precision nutrition.

Summary: This document from the Ibero-American Network of Nutriomics and Precision Nutrition (RINN22; <ext-link ext-link-type="uri" xlink:href="https://rinn22.com/" xmlns:xlink="http://www.w3.org/1999/xlink">https://rinn22.com/</ext-link>) provides a comprehensive overview of the concepts of precision nutrition approaches to guide their application in clinical and public health as well as establish the position of RINN22 regarding the current and future state of precision nutrition.

Key messages: The progress and participation of nutriomics to precision nutrition is an essential pillar for addressing diet-related diseases and developing innovative managing strategies, which will be promoted by advances in bioinformatics, machine learning, and integrative software, as well as the description of specific novel biomarkers. In this context, synthesizing and critically evaluating the latest developments, potential applications, and future needs in the field of nutrition is necessary with a holistic perspective, incorporating progress in omics technologies aimed at precision nutrition interventions. This approach must address and confront healthy, social, food security, physically active lifestyle, sanitation, and sustainability challenges with preventive, participatory, and predictive strategies of personalized, population, and planetary nutrition for a precision tailored health.

Keywords: Nutriepigenetics; Nutrigenetics; Nutrigenomics; Nutrimetabolomics; Nutrimetagenomics; Nutriomics; Precision nutrition; RINN22.

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Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

Fig. 1.
Fig. 1.
Overview of the past, present, and future of nutritional recommendations and internal and environmental factors and omics tools of an integrative precision nutrition approach.
Fig. 2.
Fig. 2.
The landscape of the eras of personalized nutrition. Levels of advice in the development of a personalized nutrition approach.
See this image and copyright information in PMC

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