Monkeypox virus isolation from longitudinal samples in 11 hospitalised patients

doi:10.1016/S1473-3099(24)00735-7

. 2025 Jan;25(1):e4-e5.

doi: 10.1016/S1473-3099(24)00735-7. Epub 2024 Nov 29.

Monkeypox virus isolation from longitudinal samples in 11 hospitalised patients

Helen Callaby¹, Janie Olver², Kirsty Emery³, Kevin S Richards⁴, Marian Killip³, Natalie Groves⁵, Mike B J Beadsworth⁶, D Ashley Price⁷, Graham S Cooke⁸, Paul Collini⁹, Joby Cole⁹, Jake Dunning¹⁰, Malcolm G Semple¹¹, J Kenneth Baillie¹²; ISARIC4C Investigators; Tommy Rampling¹³, Catherine F Houlihan¹⁴

Collaborators, Affiliations

Collaborators

ISARIC4C Investigators:
Gail Carson, Peter Openshaw, Laura Merson, Clark D Russell, Maria Zambon, Meera Chand, Richard Tedder, Saye Khoo, Peter Horby, Lance Cw Turtle, Tom Solomon, Samreen Ijaz, Tom Fletcher, Massimo Palmarini, Antonia Ho, Nicholas Price, Beatrice Alex, Petros Andrikopoulos, Benjamin Black, Wendy S Barclay, Debby Bogaert, Kanta Chechi, Ana Da Silva Filipe, Thushan De Silva, Annemarie B Docherty, Gonçalo Dos Santos Correia, Marc-Emmanuel Dumas, Christopher A Green, William Greenhalf, Julian L Griffin, Rishi Gupta, Ewen M Harrison, Karl Holden, Paul Klenerman, Andrew Law, Matthew R Lewis, Sonia Liggi, Wei Shen Lim, Lynn Maslen, Alexander J Mentzer, Alison Meynert, Shona Moore, Mahdad Noursadeghi, Michael Olanipekun, Antonia Osagie, Carlo Palmieri, William A Paxton, Georgios Pollakis, Andrew Rambaut, David Robertson, Vanessa Sancho-Shimizu, Caroline J Sands, Janet T Scott, Louise Sigfrid, Shiranee Sriskandan, David Stuart, Charlotte Summers, Olivia V Swann, Zoltan Takats, Panteleimon Takis, Aa Roger Thompson, Emma C Thomson, Ryan S Thwaites, Hayley Hardwick, Wilna Oosthuyzen, Mariles Ostermann

Affiliations

¹ Rare and Imported Pathogens Laboratory, UKHSA, Porton Down, Salisbury SP4 0JG, UK; Institute of Medical Sciences, University of Aberdeen, Abderdeen, UK.
² Rare and Imported Pathogens Laboratory, UKHSA, Porton Down, Salisbury SP4 0JG, UK.
³ High Containment & Biological Services, UKHSA, Porton Down, Salisbury, UK.
⁴ High Containment & Biological Services, UKHSA, Porton Down, Salisbury, UK; Faculty of Health and Life Sciences, Oxford Brookes University, Oxford, UK.
⁵ Genomic Public Health Analysis, UKHSA, Colindale, UK.
⁶ Tropical and Infectious Disease Unit, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
⁷ The Newcastle upon Tyne NHS Hospitals Trust, Newcastle, UK.
⁸ Department of Infectious Disease, Imperial College London, London, UK; NIHR Imperial Biomedical Research Centre, London, UK.
⁹ Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
¹⁰ Pandemic Sciences Institute, University of Oxford, Oxford, UK; Department of Infectious Diseases, Royal Free London NHS Foundation Trust, Royal Free Hospital, London, UK.
¹¹ Health Protection Research Unit in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK; Respiratory Department, Liverpool Institute for Child Health and Wellbeing, Alder Hey Children's Hospital, Liverpool, UK.
¹² Gifford Pandemic Science Hub, Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK; Intensive Care Unit, Royal Infirmary of Edinburgh, Edinburgh, UK.
¹³ Rare and Imported Pathogens Laboratory, UKHSA, Porton Down, Salisbury SP4 0JG, UK; Department of Infectious Diseases, University College London NHS Hospitals Trust, London, UK.
¹⁴ Rare and Imported Pathogens Laboratory, UKHSA, Porton Down, Salisbury SP4 0JG, UK; Department of Clinical Virology, University College London NHS Hospitals Trust, London, UK. Electronic address: catherine.houlihan5@nhs.net.

PMID: 39617024
DOI: 10.1016/S1473-3099(24)00735-7

Monkeypox virus isolation from longitudinal samples in 11 hospitalised patients

Helen Callaby et al. Lancet Infect Dis. 2025 Jan.

. 2025 Jan;25(1):e4-e5.

doi: 10.1016/S1473-3099(24)00735-7. Epub 2024 Nov 29.

Authors

Collaborators

ISARIC4C Investigators:
Gail Carson, Peter Openshaw, Laura Merson, Clark D Russell, Maria Zambon, Meera Chand, Richard Tedder, Saye Khoo, Peter Horby, Lance Cw Turtle, Tom Solomon, Samreen Ijaz, Tom Fletcher, Massimo Palmarini, Antonia Ho, Nicholas Price, Beatrice Alex, Petros Andrikopoulos, Benjamin Black, Wendy S Barclay, Debby Bogaert, Kanta Chechi, Ana Da Silva Filipe, Thushan De Silva, Annemarie B Docherty, Gonçalo Dos Santos Correia, Marc-Emmanuel Dumas, Christopher A Green, William Greenhalf, Julian L Griffin, Rishi Gupta, Ewen M Harrison, Karl Holden, Paul Klenerman, Andrew Law, Matthew R Lewis, Sonia Liggi, Wei Shen Lim, Lynn Maslen, Alexander J Mentzer, Alison Meynert, Shona Moore, Mahdad Noursadeghi, Michael Olanipekun, Antonia Osagie, Carlo Palmieri, William A Paxton, Georgios Pollakis, Andrew Rambaut, David Robertson, Vanessa Sancho-Shimizu, Caroline J Sands, Janet T Scott, Louise Sigfrid, Shiranee Sriskandan, David Stuart, Charlotte Summers, Olivia V Swann, Zoltan Takats, Panteleimon Takis, Aa Roger Thompson, Emma C Thomson, Ryan S Thwaites, Hayley Hardwick, Wilna Oosthuyzen, Mariles Ostermann

Affiliations

¹ Rare and Imported Pathogens Laboratory, UKHSA, Porton Down, Salisbury SP4 0JG, UK; Institute of Medical Sciences, University of Aberdeen, Abderdeen, UK.
² Rare and Imported Pathogens Laboratory, UKHSA, Porton Down, Salisbury SP4 0JG, UK.
³ High Containment & Biological Services, UKHSA, Porton Down, Salisbury, UK.
⁴ High Containment & Biological Services, UKHSA, Porton Down, Salisbury, UK; Faculty of Health and Life Sciences, Oxford Brookes University, Oxford, UK.
⁵ Genomic Public Health Analysis, UKHSA, Colindale, UK.
⁶ Tropical and Infectious Disease Unit, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
⁷ The Newcastle upon Tyne NHS Hospitals Trust, Newcastle, UK.
⁸ Department of Infectious Disease, Imperial College London, London, UK; NIHR Imperial Biomedical Research Centre, London, UK.
⁹ Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
¹⁰ Pandemic Sciences Institute, University of Oxford, Oxford, UK; Department of Infectious Diseases, Royal Free London NHS Foundation Trust, Royal Free Hospital, London, UK.
¹¹ Health Protection Research Unit in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK; Respiratory Department, Liverpool Institute for Child Health and Wellbeing, Alder Hey Children's Hospital, Liverpool, UK.
¹² Gifford Pandemic Science Hub, Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK; Intensive Care Unit, Royal Infirmary of Edinburgh, Edinburgh, UK.
¹³ Rare and Imported Pathogens Laboratory, UKHSA, Porton Down, Salisbury SP4 0JG, UK; Department of Infectious Diseases, University College London NHS Hospitals Trust, London, UK.
¹⁴ Rare and Imported Pathogens Laboratory, UKHSA, Porton Down, Salisbury SP4 0JG, UK; Department of Clinical Virology, University College London NHS Hospitals Trust, London, UK. Electronic address: catherine.houlihan5@nhs.net.

PMID: 39617024
DOI: 10.1016/S1473-3099(24)00735-7

No abstract available

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Conflict of interest statement

CFH received funding for this study from the Healthcare Infection Society (SRG/2022/03/002), via the UK Health Security Agency. The funders of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. JD, MGS, JKB, and ISARIC4C are supported by the National Institute for Health and Care Research (NIHR) Health Protection Research Unit in Emerging and Zoonotic Infections at the University of Liverpool in partnership with the UK Heath Security Agency, in collaboration with Liverpool School of Tropical Medicine and the University of Oxford (NIHR award 200907). The research was supported by The Pandemic Institute, formed of seven founding partners: The University of Liverpool, Liverpool School of Tropical Medicine, Liverpool John Moores University, Liverpool City Council, Liverpool City Region Combined Authority, Liverpool University Hospital Foundation Trust, and Knowledge Quarter Liverpool. MGS is based at The University of Liverpool. The views expressed are those of the author(s) and not necessarily those of The Pandemic Institute. MGS has additionally received funding for this work from the UK Medical Research Council. MGS is an independent external and non-remunerated member of Pfizer's External Data Monitoring Committee for their mRNA vaccine programme(s); Chair of Infectious Disease Scientific Advisory Board for Integrum Scientific, Greensboro, NC, USA; and director and majority shareholder of MedEx Solutions. MGS is minority shareholder in Integrum Scientific, Greensboro, NC, USA. MGS has received gifts to their institution in the form of investigational medicinal product from Chiesi Farmaceutici. All other authors declare no competing interests. HC, CH, TR, JO, and KR accessed and verified the data in this study. Information on ethical approvals is provided in the appendix (p 6). The ISARIC4C investigators are listed in the appendix (pp 1–2).

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Monkeypox virus isolation from longitudinal samples in 11 hospitalised patients

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Monkeypox virus isolation from longitudinal samples in 11 hospitalised patients

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Conflict of interest statement

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