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Editorial
. 2025 Jul;41(7):2419-2421.
doi: 10.1016/j.arthro.2024.11.076. Epub 2024 Nov 29.

Editorial Commentary: Anterior Cruciate Ligament Allograft Is Rarely Indicated But May Be Considered for Older, Low-Physical Demand Patients

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Editorial

Editorial Commentary: Anterior Cruciate Ligament Allograft Is Rarely Indicated But May Be Considered for Older, Low-Physical Demand Patients

Joseph D Lamplot et al. Arthroscopy. 2025 Jul.

Abstract

Graft selection for anterior cruciate ligament reconstruction (ACLR) remains controversial. In addition, an increasing number of ACLRs are being performed in an aging population, creating a potential gap in evidence. The goal is to restore functional stability to the knee; minimize the likelihood of graft failure; and provide patient satisfaction, achieved primarily by a patient's ability to return to unrestricted physical activity. Because of an unacceptably high risk of allograft failure in younger patients, the use of allograft for ACLR has substantially decreased over the past 2 decades. However, postoperative activity, rather than age in isolation, determines the success of allograft ACLR. Whereas allograft is rarely indicated in patients who regularly participate in cutting and pivoting activities, regardless of age, a patient-specific approach should consider age, potential donor-site morbidity, and postoperative activity goals. In our experience, allograft ACLR is not indicated in patients younger than 35 years (with very rare exceptions of sedentary individuals preferring to minimize donor-site morbidity). Allograft is not recommended in any patient, regardless of age, who regularly participates in cutting and pivoting sports, particularly level I sports that include jumping, cutting, and hard pivoting. Finally, although surgeons should err toward using autograft when in doubt, allograft may be selectively indicated in older and low-physical demand patients.

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Conflict of interest statement

Disclosures The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: J.D.L. reports a consulting or advisory relationship with Vericel; receives funding grants from Arthrex; receives travel reimbursement from Stryker Orthopaedics; is on the Arthroscopy Editorial Board; and is on the Research Committee of American Orthopaedic Society for Sports Medicine. G.D.M. receives funding grants from Arthrex; consults with commercial entities to support commercialization strategies but has no direct financial interest in commercialization of the products; and receives author royalties from Human Kinetics and Wolters Kluwer. His institution has received grant funding in the past and is receiving current and ongoing grant funding from National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases (grants U01AR067997, R01AR070474, R01AR055563, R01AR076153, R01AR077248, and R61AT012421), Department of Defense (grant W81XWH22C0062), Department of Veterans Affairs (CReATE Motion Center), and Arthritis Foundation Osteoarthritis Clinical Trial Network; has received industry-sponsored research funding to his institution related to injury prevention and sports performance and is receiving current ongoing funding from Arthrex to evaluate ACL surgical treatment optimization strategies; is an inventor of biofeedback technologies designed to enhance rehabilitation and prevent injuries (patent US11350854B2, Augmented and Virtual Reality for Sport Performance and Injury Prevention Application; approved June 7, 2022; software copyrighted), for which he receives licensing royalties. S.A.L. is on the Arthroscopy Editorial Board and is a board member of Eastern Orthopedic Association.

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