Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Dec;56(12):2551-2558.
doi: 10.1038/s12276-024-01348-2. Epub 2024 Dec 2.

Noncoding RNA as a crucial epigenetic modulator in the degeneration of the ligamentum flavum

Yongzhao Zhao #  1   2   3 , Qian Xiang #  1   2   3 , Shuo Tian #  1   2   3 , Zhenquan Wu #  1   2   3 , Jialiang Lin  1   2   3 , Longjie Wang  1   2   3 , Zhuoran Sun  1   2   3 , Weishi Li  4   5   6
Affiliations
Review

Noncoding RNA as a crucial epigenetic modulator in the degeneration of the ligamentum flavum

Yongzhao Zhao et al. Exp Mol Med. 2024 Dec.

Abstract

Ligamentum flavum degeneration, including hypertrophy and ossification of the ligamentum flavum, leads to degenerative spinal stenosis in older adults. However, the underlying mechanisms of ligamentum flavum degeneration remain unclear, and therapeutic strategies are limited. Noncoding RNAs include microRNAs, circular RNAs, and long noncoding RNAs. As important epigenetic modifications, noncoding RNAs are involved in the progression of several age-related diseases, including ligamentum flavum degeneration. Previous studies have shown that noncoding RNAs can regulate the osteogenic differentiation and fibrosis of ligamentum flavum cells by regulating the expression of related genes. In this review, we discuss noncoding RNAs and their role in ligamentum flavum degeneration.

PubMed Disclaimer

Conflict of interest statement

Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Overview of ncRNAs involved in LF degeneration.
This figure illustrates the landscape of function and expression of ncRNAs in LF across different pathological states. LF ligamentum flavum, ncRNA non-coding RNA.
See this image and copyright information in PMC

References

    1. Austevoll, I. M. et al. Decompression with or without fusion in degenerative lumbar spondylolisthesis. N. Engl. J. Med.385, 526–538 (2021). - PubMed
    1. Katz, J. N., Zimmerman, Z. E., Mass, H. & Makhni, M. C. Diagnosis and management of lumbar spinal stenosis: a review. Jama327, 1688–1699 (2022). - PubMed
    1. Chen, Z. Q. & Sun, C. G. Clinical guideline for treatment of symptomatic thoracic spinal stenosis. Orthop. Surg.7, 208–212 (2015). - PMC - PubMed
    1. Byvaltsev, V. A. et al. Molecular and genetic mechanisms of spinal stenosis formation: systematic review. Int. J. Mol. Sci.23, 13479 (2022). - PMC - PubMed
    1. Shin, H. K., Seo, K. J., Lee, J. Y., Jeon, S. R. & Yune, T. Y. GSK-3β and β-catenin signaling pathway is involved in myofibroblast transition of ligamentum flavum in lumbar spinal stenosis patients. Spine48, 1472–1479 (2023). - PubMed

LinkOut - more resources