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. 2024 Dec 1;76(1):154.
doi: 10.1186/s43044-024-00583-2.

Thrombus aspiration in primary percutaneous coronary intervention in acute ST-elevation myocardial infarction patients with high thrombus burden: one-year outcomes in a tertiary healthcare center in Ho Chi Minh City

Duy Cao Phuong Le  1   2 , Giang Thai Pham  3 , Quan Duy Vo  4   5
Affiliations

Thrombus aspiration in primary percutaneous coronary intervention in acute ST-elevation myocardial infarction patients with high thrombus burden: one-year outcomes in a tertiary healthcare center in Ho Chi Minh City

Duy Cao Phuong Le et al. Egypt Heart J. .

Abstract

Background: Primary percutaneous coronary intervention (PCI) can dislodge atherosclerotic debris, risking microvascular embolism. Thrombus aspiration (TA) before stenting in ST-segment elevation myocardial infarction (STEMI) patients has been linked to reduced mortality, lower recurrence of heart attacks, and improved cardiac function. However, limited research exists on the effectiveness of TA in Vietnam, underscoring the need for further studies to enhance cardiovascular care. This prospective observational study was conducted to evaluate the role of TA in STEMI patients admitted with a substantial thrombus burden at Nguyen Tri Phuong Hospital.

Results: Out of 92 participants, 68 underwent TA treatment. Post-treatment, the TA group exhibited better TIMI and TMP flow grades and a higher rate of ST-segment normalization, with no significant difference in major adverse cardiac events (MACEs) at 30-day and 12-month follow-ups compared to those untreated.

Conclusions: TA during PCI enhances ST-segment normalization and TIMI and TMP scores in STEMI patients, improving myocardial perfusion. No difference in MACE occurrence was noted between groups after 30 days and 12 months, suggesting TA's potential benefits without increasing adverse outcomes.

Keywords: Major adverse cardiovascular events; Percutaneous coronary intervention; STEMI; Thrombus aspiration; Thrombus burden.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: The study design was revised and approved by the Ethical Committee at Nguyen Tri Phương Hospital (No. HĐĐĐ-NTP/263) following the Declaration of Helsinki. A written consent was provided by all the study participants after explanation of the study steps. Consent for publication: Written informed consents were obtained and available for review by the Editor-in-Chief of this journal on request. Competing interests: The authors report no declarations of interest.

Figures

Fig. 1
Fig. 1
Study flowchart
Fig. 2
Fig. 2
Factors related to successful TA
Fig. 3
Fig. 3
MACE comparison between TA and non-TA in STEM
See this image and copyright information in PMC

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