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. 2025 Oct;29(5):4463-4478.
doi: 10.1007/s11030-024-11049-7. Epub 2024 Dec 2.

Chalcone derivatives containing 1,2,4-triazole and pyridine moiety: design, synthesis, and antiviral activity

Hui Xin  1 , Jiao Tian  1 , Tianyu Deng  1 , Qing Zhou  1 , Yuhong Wang  1 , Hong Fu  1 , Haotao Pu  1 , Wei Xue  2
Affiliations

Chalcone derivatives containing 1,2,4-triazole and pyridine moiety: design, synthesis, and antiviral activity

Hui Xin et al. Mol Divers. 2025 Oct.

Abstract

A series of chalcone derivatives containing 1,2,4-triazole and pyridine were designed and synthesized, and their antiviral activities against tobacco mosaic virus (TMV) were evaluated. Notably, S7 (EC50 = 89.7 μg/mL) exhibited excellent curative activity against the TMV, which was superior to that of ningnanmycin (NNM: EC50 = 201.7 μg/mL). Molecular docking showed that S7 exhibited satisfactory affinities for the TMV coat protein (TMV-CP), with four strong conventional hydrogen bonds with amino acid residues. Further, microscale thermophoresis (MST) showed that S7 (Kd = 0.5340 ± 0.2233 μmol/L) bound more strongly to TMV-CP than NNM (Kd = 5.1186 ± 1.9568 μmol/L). The results of chlorophyll content, malondialdehyde (MDA) content, and biological enzyme activity confirmed that S7 enhanced the disease resistance of tobacco plants by affecting the change of chlorophyll content, interfering with plant lipid peroxidation, and enhancing SOD activity in plants, respectively.

Keywords: 1,2,4-triazole; Antiviral activity; Chalcone; Pyridine; TMV-CP.

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Conflict of interest statement

Declarations. Conflict of interest: The authors declare no competing financial interest.

References

    1. Bos L (1982) Crop losses caused by viruses. Crop Prot 1:263–282. https://doi.org/10.1016/0261-2194(82)90002-3 - DOI
    1. Tai GY, Zhang Q, He JQ, Li XY, Gan XH (2024) Ferulic acid dimers as potential antiviral agents by inhibiting TMV self-assembly. J Agric Food Chem 72:14610–14619. https://doi.org/10.1021/acs.jafc.4c03713 - DOI - PubMed
    1. Ge YH, Liu KX, Zhang JX, Mu SZ, Hao XJ (2012) The limonoids and their antitobacco mosaic virus (TMV) activities from munronia unifoliolata oliv. J Agric Food Chem 60:4289–4295. https://doi.org/10.1021/jf205362d - DOI - PubMed
    1. Han GF, Chen LW, Wang Q, Wu M, Liu YX, Wang QM (2018) Design, synthesis, and antitobacco mosaic virus activity of water-soluble chiral quaternary ammonium salts of phenanthroindolizidines alkaloids. J Agric Food Chem 66:780–788. https://doi.org/10.1021/acs.jafc.7b03418 - DOI - PubMed
    1. Han YG, Luo Y, Qin SR, Xi L, Wan B, Du LF (2014) Induction of systemic resistance against tobacco mosaic virus by ningnanmycin in tobacco. Pestic Biochem Physiol 111:14–18. https://doi.org/10.1016/j.pestbp.2014.04.008 - DOI - PubMed

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