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Review
. 2024 Nov 15:14:1480683.
doi: 10.3389/fonc.2024.1480683. eCollection 2024.

Progress and perspectives on BMP9-ID1 activation of HIF-1α and VEGFA to promote angiogenesis in hepatic alveolar echinococcosis

Fei Ke  1 , Meng-Zhao Xu  1 , Long Ma  2 , Qi-Dong Chen  2 , Bei-Bei He  3 , Ji-De A  4
Affiliations
Review

Progress and perspectives on BMP9-ID1 activation of HIF-1α and VEGFA to promote angiogenesis in hepatic alveolar echinococcosis

Fei Ke et al. Front Oncol. .

Abstract

Hepatic alveolar echinococcosis is a zoonotic disease with a high incidence in western China, particularly affecting plateau areas such as Qinghai, Tibet, and Xinjiang. Research has indicated the presence of neovascularization in the peripheral infiltration area of hepatic alveolar echinococcosis, with a strong correlation between angiogenesis and vascular endothelial growth factor A (VEGFA) and hypoxia-inducible factor 1-alpha (HIF-1α) overexpression. Given the similarities between hepatic alveolar echinococcosis and liver cancer, current research is focused on treating the disease by targeting related signaling pathways using molecular drugs used for liver cancer. This article aims to summarize the biological regulation of HIF-1α and VEGFA overexpression in angiogenesis related to hepatic alveolar echinococcosis, as well as the impact of the BMP9-ID1 signaling pathway on the expression levels of HIF-1α and VEGFA, providing new insights for potential treatment strategies.

Keywords: BMP9; HIF-1α; ID1; VEGFA; angiogenesis; hepatic alveolar echinococcosis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Mechanism of BMP9 and ID1 signaling on HIF-1α/VEGFA/VEGFR2 signaling pathway.
See this image and copyright information in PMC

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