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. 2024 Nov 15:15:1454586.
doi: 10.3389/fphar.2024.1454586. eCollection 2024.

Focus on podocytes: diabetic kidney disease and renal fibrosis - a global bibliometric analysis (2000-2024)

Dong-Yang An  1   2   3 , Jun Tan  4 , Yan-Dan Lu  1 , Ze-Huai Wen  5 , Yi-Ni Bao  1 , Zhou-Hui Yao  1 , Zi-Yan Chen  1 , Ping-Ping Wang  1 , Wei Zhou  6 , Qiao Yang  1 , Min Hao  1
Affiliations

Focus on podocytes: diabetic kidney disease and renal fibrosis - a global bibliometric analysis (2000-2024)

Dong-Yang An et al. Front Pharmacol. .

Abstract

Background: Diabetic kidney disease (DKD) is a common pathway to End-stage renal disease (ESRD). Podocytes are crucial due to their dual barrier functions in kidney diseases. Their role in renal fibrosis and DKD regulatory mechanisms is increasingly studied. However, bibliometric research in this field has not been explored.

Methods: 1,250 publications from Jan. 1, 2000, to Feb. 16, 2024, were retrieved from the WoSCC database and analyzed by the Web of Science results analysis tool, VOSviewer, and CiteSpace.

Results: Our scrutiny reveals that authors Liu Youhua, Fogo Agnes B, and Zhao Yingyong have made substantial contributions to this domain. Notably, "Kidney International" has the highest volume of publications in this area. Furthermore, our analysis identifies ten co-citation clusters: DKD, IncRNA, reactive oxygen species, glomerulosclerosis, Poria cocos, glomerular diseases, fibroblasts, connective tissue growth factor, coagulation, and Wnt. Recent research accentuates keywords such as autophagy, TRPC6, ERS, epigenetics, and NLRP3 inflammasome as frequently occurring terms in this field. The prevailing research hotspot keywords include autophagy, biomarker, and exosomes.

Conclusion: Through the utilization of bibliometric tools and knowledge graph analysis, we have undertaken a comprehensive review of the intricate nexus between podocytes in DKD and renal fibrosis. This study imparts valuable insights to scholars regarding the dynamic evolution of this association and delineates prospective research avenues in this pivotal realm.

Keywords: DKD; Poria cocos; holistic integrated medicine; podocytes; renal fibrosis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Analysis of publications, countries/regions and institutions. (A) Visually encapsulates the annual evolution and cumulative publication trends pertinent to this domain, spotlighting the top 10 countries at the forefront of this research endeavor. (B) Collaborative academic endeavors among countries/regions. (C) Institutional collaborative network via VOSviewer. (D) Global publication landscape.
FIGURE 2
FIGURE 2
Collaborative network of authors. A visual representation delineating the cooperative networks and interactions among authors engaged in the study of this subject.
FIGURE 3
FIGURE 3
Dual-map overlap of journals in kidney repair research. A visual representation depicting the dual-mapping of journals engaged in the discourse surrounding kidney repair within the context of this research domain.
FIGURE 4
FIGURE 4
Analysis of co-cited references. (A) Cluster diagram of co-cited references with keywords as label source. (B) Temporal perspective on co-cited references through keywords. (C) Top 25 references with strongest citation bursts (red represents the outbreak time range).
FIGURE 5
FIGURE 5
Analysis of keywords. (A) Cluster network of co-occurring author keywords and their temporal evolution. (B) Top 20 keywords with the strongest citation bursts (red represents the outbreak time range).
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