Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Sep 24;12(11):8623-8650.
doi: 10.1002/fsn3.4469. eCollection 2024 Nov.

On the health effects of curcumin and its derivatives

Hudda Ayub  1 , Mahad Islam  2 , Munnaza Saeed  1 , Husnat Ahmad  1 , Fahad Al-Asmari  3 , Mohamed Fawzy Ramadan  4 , Mohammed Alissa  5 , Muhammad Adnan Arif  6 , Muhammad Umair Jamil Rana  1 , Muhammad Subtain  1 , Muhammad Abdul Rahim  7 , Eliasse Zongo  8 , Nazir Ahmad  9
Affiliations
Review

On the health effects of curcumin and its derivatives

Hudda Ayub et al. Food Sci Nutr. .

Abstract

Turmeric (Curcuma longa) is an herbaceous plant that contains a phytochemical which is bright yellow and is known as curcumin. Turmeric, a member of Zingiberaceae family, has extensive application worldwide due to its beneficial medicinal attributes and is extensively used as a medicinal plant. Most people use turmeric as a spice, and it is a chief source of polyphenol curcumin. Curcuma longa has therapeutic properties, and since the initial extraction of curcumin from this plant, it has gained prodigious consideration from scientists in the medical field. The biological properties of curcumin, also known as 1,7-bis (4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, or diferuloylmethane, include anti-inflammatory, anti-oxidant, anti-cancer, anti-asthmatic, anti-arthritic, neuroprotective, anti-diabetic, anti-obesity, wound-healing, hepatoprotective, skin curative, reproductive role, etc. This work has reviewed many clinical trials and their findings about these activities. The focus of this review manuscript is concentrated on the presently existing clinical and animal studies, which exposed the possible anti-retroviral activities of curcumin and its by-products.

Keywords: Curcuma longa; anti‐asthmatic; anti‐inflammatory; anti‐obesity; curcumin; diferuloylmethane; pharmacological activity.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

FIGURE 1
FIGURE 1
The diagram of the entire curcumin plant.
FIGURE 2
FIGURE 2
Chemical structure of curcumin.
FIGURE 3
FIGURE 3
Metabolite derivatives of curcumin.
FIGURE 4
FIGURE 4
Health effects of curcumin.
FIGURE 5
FIGURE 5
Curcumin derivatives have anti‐oxidant activity.
FIGURE 6
FIGURE 6
Curcumin analogs with strong anti‐breast cancer action.
FIGURE 7
FIGURE 7
An analog of curcumin that fights lung cancer.
FIGURE 8
FIGURE 8
Activity of curcumin analogs versus prostatic cancer.
FIGURE 9
FIGURE 9
Compounds of turmeric that fight pancreatic cancer.
FIGURE 10
FIGURE 10
Curcumin derivatives in treatment of CVDs.
FIGURE 11
FIGURE 11
An analog of curcumin with strong anti‐inflammatory properties.
FIGURE 12
FIGURE 12
Curcumin derivative with anti‐Alzheimer activity.
See this image and copyright information in PMC

References

    1. Abdel‐Daim, M. M. , & Abdou, R. H. (2015). Protective effects of diallyl sulfide and curcumin separately against thallium‐induced toxicity in rats. Cell Journal, 17(2), 379. - PMC - PubMed
    1. Adhvaryu, M. R. , Reddy, N. M. , & Vakharia, B. C. (2008). Prevention of hepatotoxicity due to anti tuberculosis treatment: A novel integrative approach. World Journal of Gastroenterology: WJG, 14(30), 4753–4762. - PMC - PubMed
    1. Afshariani, R. , Farhadi, P. , Ghaffarpasand, F. , & Roozbeh, J. (2014). Effectiveness of topical curcumin for treatment of mastitis in breastfeeding women: A randomized, double‐blind, placebo‐controlled clinical trial. Oman Medical Journal, 29(5), 330–334. - PMC - PubMed
    1. Aggarwal, B. B. (2010). Targeting inflammation‐induced obesity and metabolic diseases by curcumin and other nutraceuticals. Annual Review of Nutrition, 30, 173–199. - PMC - PubMed
    1. Aggarwal, B. B. , & Harikumar, K. B. (2009). Potential therapeutic effects of curcumin, the anti‐inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. The International Journal of Biochemistry & Cell Biology, 41(1), 40–59. - PMC - PubMed

LinkOut - more resources