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Case Reports
. 2025 May;40(5):1595-1597.
doi: 10.1007/s00467-024-06613-0. Epub 2024 Dec 2.

A hypertensive adolescent with aripiprazole-induced hyperaldosteronism

Pelin Abdal Yıldırım  1 , Eren Soyaltın  2   3 , Cemaliye Başaran  2   3 , Seçil Arslansoyu Çamlar  2   4 , Belde Kasap Demir  2   3
Affiliations
Case Reports

A hypertensive adolescent with aripiprazole-induced hyperaldosteronism

Pelin Abdal Yıldırım et al. Pediatr Nephrol. 2025 May.

Abstract

Background: Aripiprazole-associated hypertension is a previously described side effect, but its mechanism has not been clearly elucidated. Here we present a 16-year-old male patient who developed aripiprazole-associated hypertension, and we discuss the mechanisms that may cause hypertension.

Case diagnosis: Antipsychotic drugs are beneficial for the control of mental health conditions. In this report, we present a case of a patient who developed hypertension after using aripiprazole. A 16-year-old male patient was admitted with headache and high blood pressure. In the examinations conducted for etiology, the aldosterone/plasma renin activity (PRA) was found to be high, but in follow-up, hypertension regressed and aldosterone/PRA were detected normal. The patient was questioned again in terms of medical history. It was learned that the patient was initiated on aripiprazole, and hypertension developed after the drug. The aldosterone/PRA was studied 15 days after he stopped the drug. In this patient, hypertension and hyperaldosteronism were associated with aripiprazole.

Keywords: Aripiprazole; Hyperaldosteronism; Hypertension.

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Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests.

References

    1. Uzun AD, Sapmaz ŞY, Öztürk M, Kandemir H (2019) Hypertension induced by aripiprazole use in an autistic child patient. Clin Psychopharmacol Neurosci 17:556–558. https://doi.org/10.9758/cpn.2019.17.4.556 - DOI - PubMed - PMC
    1. Alves BB, Oliveira GP, Moreira Neto MG, Fiorilli RB, Cestário EDES (2019) Use of atypical antipsychotics and risk of hypertension: a case report and review literature. SAGE Open Med Case Rep 7:2050313X19841825. https://doi.org/10.1177/2050313X19841825
    1. Shapiro DA, Renock S, Arrington E, Chiodo LA, Liu LX, Sibley DR, Roth BL, Mailman R (2003) Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology. Neuropsychopharmacology 28:1400–1411. https://doi.org/10.1038/sj.npp.1300203 - DOI - PubMed
    1. Gonsai NH, Amin VH, Mendpara CG, Speth R, Hale GM (2018) Effects of dopamine receptor antagonist antipsychotic therapy on blood pressure. J Clin Pharm Ther 43:1–7. https://doi.org/10.1111/jcpt.12649 - DOI - PubMed
    1. Pivonello R, Ferone D, de Herder WW, de Krijger RR, Waaijers M, Mooij DM, van Koetsveld PM, Barreca A, De Caro ML, Lombardi G, Colao A, Lamberts SW, Hofland LJ (2004) Dopamine receptor expression and function in human normal adrenal gland and adrenal tumors. J Clin Endocrinol Metab 89:4493–4502. https://doi.org/10.1210/jc.2003-031746 - DOI - PubMed

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