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. 2024 Dec 2;148(1):77.
doi: 10.1007/s00401-024-02827-6.

MN1 immunohistochemistry is a sensitive diagnostic biomarker for primitive CNS tumors with MN1 fusion

Roxane Daniel  1 , Arnault Tauziède-Espariat  2 , Alice Métais  3   4 , Charlotte Berthaud  3 , Noémie Pucelle  3 , Joelle Lacombe  1 , Aurélien Collard  1 , Fabrice Chrétien  1   3 , Pascale Varlet  3   4
Affiliations

MN1 immunohistochemistry is a sensitive diagnostic biomarker for primitive CNS tumors with MN1 fusion

Roxane Daniel et al. Acta Neuropathol. .
No abstract available

Keywords: Astroblastoma; Immunohistochemistry; MN1.

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Conflict of interest statement

Declarations. Conflict of interest: The authors declare that they have no conflict of interest directly related to the topic of this article.

Figures

Fig. 1
Fig. 1
Expression of MN1 in primitive CNS tumors, comparing hematoxylin phloxine saffron staining with MN1 IHC. There is diffuse and strong MN1 expression in tumors with MN1 fusion, particularly astroblastoma, MN1::BEND2-fused (B), ZFTA::MN1 (P), PATZ1::MN1 (R), as well as meningioma (F) and in unexpected tumors with no MN1 fusion like SUBEPN (N), SEGA (T), tumors with EP300::BCOR (V), central neurocytoma (X) and IMT FET::CREB (Z). Conversely, no MN1 expression is observed in tumors like astroblastoma BEND2-altered (D), ZFTA::RELA (H), PXA (J), glioblastoma IDH-WT mesenchymal subtype (L) and PATZ1::EWSR1 (Z’). Scale bars: 50 µm
See this image and copyright information in PMC

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