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. 2025 Feb;24(2):151-152.
doi: 10.1038/s41573-024-01102-3.

Antiviral target compound profile for pandemic preparedness

James F Demarest  1 , Ruxandra Draghia-Akli  1 , Tomas Cihlar  1   2 , Kenneth Bradley  1   3 , John A T Young  1   3 , Richa Chandra  4 , Sujata Vaidyanathan  4 , Margaret Chu-Moyer  5 , Christopher L Lynch  6 , Andrew Campbell  6 , Kumar Singh Saikatendu  7 , John P Bilello  2 , Yoshihiko Murata  2 , Marnix van Loock  8 , Aeron C Hurt  9 , Timothy Tellinghuisen  3 , Lee Ruggiero  1 , Richard Mackman  1 , Nina M Hill  1 , John C Pottage Jr  10 ; INTREPID Alliance
Collaborators, Affiliations

Antiviral target compound profile for pandemic preparedness

James F Demarest et al. Nat Rev Drug Discov. 2025 Feb.
No abstract available

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Conflict of interest statement

Competing interests: T.C., J.P.B., and Y.M. are employees of Gilead Sciences. K.B., J.A.T.Y., A.C.H., and T.T. are employees of F. Hoffmann-LaRoche. R.C. and S.V. are employees of Novartis Pharmaceuticals. C.L.L and A.C. are employees of AbbVie. M.v.L. is an employee of Janssen Pharmaceutica. J.F.D., R.D.-A., K.S.S., M.C.-M., L.R., R.M., N.M.H, and J.C.P. declare no competing interests.

References

    1. von Delft, A. et al. Accelerating antiviral drug discovery: lessons from COVID-19. Nat. Rev. Drug Discov. 22, 585–603 (2023). - DOI
    1. Guidance for Industry and Review Staff: Target Product Profile — A Strategic Development Process Tool (US Food & Drug Administration, 2007); https://fda.report/media/72566/Target-Product-Profile----A-Strategic-Development-Process-Tool.pdf .
    1. Target Product Profiles for Antivirals (National Institute of Allergy and Infectious Disease, 2024); https://www.niaid.nih.gov/research/target-product-profiles-antivirals .
    1. Target product profiles. Drugs for Neglected Diseases Initiative (2024); https://dndi.org/research-and-development/target-product-profiles/ .
    1. Links to WHO target product profiles (TPPs) and product profile characteristics (PPCs). World Health Organization (2024); https://www.who.int/observatories/global-observatory-on-health-research-... .

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