European Respiratory Society Research Seminar on Preventing Pediatric Asthma

Jonathan Grigg^{1

2}, Benjamin Barratt³, Klaus Bønnelykke⁴, Adnan Custovic⁵, Markus Ege^{1

6}, Christian Pasquali⁷, Oscar Palomares⁸, Seif Shaheen^{9

10}, Milena Sokolowska¹¹, Donata Vercelli^{12

13

14

15}, Rick Maizels¹⁶, Erika von Mutius¹

Affiliations

¹ Institute of Asthma and Allergy Prevention, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
² Blizard Institute, Queen Mary University of London, London, UK.
³ MRC Centre for Environment and Health, Environmental Research Group, Imperial College London, London, UK.
⁴ Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital, Copenhagen, Denmark.
⁵ National Heart and Lung Institute, Imperial College London, London, UK.
⁶ Dr von Hauner Children's Hospital, Ludwig Maximilian University; Institute of Asthma and Allergy prevention, Helmholtz Centre Munich; Comprehensive Pneumology Center Munich (CPC-M), German Center for Lung Research, Munich, Germany.
⁷ Department of Preclinical Research, OM Pharma SA, Meyrin, Switzerland.
⁸ Department of Biochemistry and Molecular Biology, School of Chemistry, Complutense University of Madrid, Madrid, Spain.
⁹ Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
¹⁰ Allergy and Lung Health Unit, Melbourne School of Population and Global Health, The University of Melbourne, Victoria, Australia.
¹¹ Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland.
¹² Department of Cellular and Molecular Medicine, The University of Arizona, Tucson, Arizona, USA.
¹³ Asthma and Airway Disease Research Center, The University of Arizona, Tucson, Arizona, USA.
¹⁴ The BIO5 Institute, The University of Arizona, Tucson, Arizona, USA.
¹⁵ Arizona Center for the Biology of Complex Diseases, The University of Arizona, Tucson, Arizona, USA.
¹⁶ Wellcome Centre of Integrative Parasitology, School of Infection and Immunity, University of Glasgow, Glasgow, UK.

PMID: 39625247
PMCID: PMC11748117
DOI: 10.1002/ppul.27401

Review

European Respiratory Society Research Seminar on Preventing Pediatric Asthma

Jonathan Grigg et al. Pediatr Pulmonol. 2025 Jan.

. 2025 Jan;60(1):e27401.

doi: 10.1002/ppul.27401. Epub 2024 Dec 3.

Authors

Affiliations

¹ Institute of Asthma and Allergy Prevention, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
² Blizard Institute, Queen Mary University of London, London, UK.
³ MRC Centre for Environment and Health, Environmental Research Group, Imperial College London, London, UK.
⁴ Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital, Copenhagen, Denmark.
⁵ National Heart and Lung Institute, Imperial College London, London, UK.
⁶ Dr von Hauner Children's Hospital, Ludwig Maximilian University; Institute of Asthma and Allergy prevention, Helmholtz Centre Munich; Comprehensive Pneumology Center Munich (CPC-M), German Center for Lung Research, Munich, Germany.
⁷ Department of Preclinical Research, OM Pharma SA, Meyrin, Switzerland.
⁸ Department of Biochemistry and Molecular Biology, School of Chemistry, Complutense University of Madrid, Madrid, Spain.
⁹ Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
¹⁰ Allergy and Lung Health Unit, Melbourne School of Population and Global Health, The University of Melbourne, Victoria, Australia.
¹¹ Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland.
¹² Department of Cellular and Molecular Medicine, The University of Arizona, Tucson, Arizona, USA.
¹³ Asthma and Airway Disease Research Center, The University of Arizona, Tucson, Arizona, USA.
¹⁴ The BIO5 Institute, The University of Arizona, Tucson, Arizona, USA.
¹⁵ Arizona Center for the Biology of Complex Diseases, The University of Arizona, Tucson, Arizona, USA.
¹⁶ Wellcome Centre of Integrative Parasitology, School of Infection and Immunity, University of Glasgow, Glasgow, UK.

PMID: 39625247
PMCID: PMC11748117
DOI: 10.1002/ppul.27401

Abstract

This report is a summary of the presentations given at the European Respiratory Society's Research Seminar on Asthma Prevention. The seminar reviewed both epidemiological and mechanistic studies and concluded that; (i) reducing exposure of pregnant women and children to air pollution will reduce incident asthma, (ii) there are promising data that both fish oil and a component of raw cow's milk prevent asthma, and (iii) modulating trained immunity by either mimicking helminth infection or oral and sublingual bacterial products is a promising area of research.

Keywords: asthma; children; prevention.

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Conflict of interest statement

The research seminar was supported by a grant from the European Respiratory Society. J.G. Support; NIHR Senior Investigator Award, Grants; OM Pharma, Marinomed; Advisory board; OM Pharma, Omron, Honoraria; AstraZeneca, Equipment and materials donation; OM Pharma, Immunotek S.L., Omron, Payment for medical evidence; Hogg Robertson Solicitors. K.B. Honoraria; Sanofi and AstraZeneca, Meeting support; ALK‐Abelló Nordic, Advisory Board; ALK‐Abelló Nordic. A.C. Grants: Medical Research Council, EPSRC, Wellcome Trust, Consulting fees; Sanofi, Reacta Biotech, Honoraria; GSK AstraZeneca, Sanofi, Stallergens‐Greer, La Roche Possay, Board Member; World Allergy Organization. M.E. Grants; German Federal Ministry of Education and Research, Dutch Longfonds, Bavarian State Ministry of Health and Care, Patents; EP000002361632B1, EP1964570B1, Equipment donation; Royal Friesland Campina. M.S. Grants; Swiss National Science Foundation (SNSF) nr 189334/1 and 224154, GSK, Novartis, Stiftung vorm. Bündner Heilstätte Arosa and OM Pharma; Speaker's fee; AstraZeneca. Board Member; EAACI. C.P. Support; Employee of OM Pharma, Patents; US20220143111A1, WO2020182970A, Shares; OM Pharma. P.O. Grants; UCM‐Inmunotek S.L, Comunidad Autónoma de Madrid (CAM), MICINNIN, Consulting fees; AstraZeneca, Pfizer, GlaxoSmithKline, Inmunotek S.L, Novartis, Sanofi‐Genzyme, Honoraria; AstraZeneca, Pfizer, GlaxoSmithKline, Inmunotek S.L, Novartis, Sanofi‐Genzyme, Advisory Board; AstraZeneca, Pfizer, GlaxoSmithKline, Inmunotek S.L, Novartis, Sanofi‐Genzyme, Board Member; EAACI. D.V Grants; National Institute of Health. E.v.M. Grants; German Research Foundation (DFG), German Federal Ministry of Education and Research (BMBF), German Center for Lung Research, Bavarian State Ministry of Health and Care, OM Pharma S.A, BMBF (Federal Ministry of Education and Research), European Research Council, Royalties/licences; Elsevier GmbH, Georg Thieme Verlag, Springer‐Verlag GmbH, Elsevier Ltd, Springer Nature Group, Deutscher Apotheker Verlag, Honoraria; ALK‐Abello Arzneimittel GmbH, Japanese Society of Pediatric Allergy and Clinical Immunology (JSPACI), Klinikum Rechts der Isar, University of Colorado, Paul‐Martini‐Stiftung, Astra Zeneca BioPharmaceuticals Medical, Imperial College London, Children's Hospital Research Institute of Manitoba Kompetenzzentrum für Ernährung (Kern), OM Pharma S.A. Swedish Pediatric Society for Allergy and Lung Medicine, Chinese College of Allergy and Asthma (CCAA), Abbott Laboratories, Deutscher Apotheker Verlag GmbH & Co. KG, Socieded Chilena de Enfermedades Respiratorias, Japanese Society of Allergology, British Society for Asthma and Clinical Immunology, American Academy of Allergy, Asthma & Immunology, European Respiratory Society. The remaining authors declare no conflicts of interest.

References

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European Respiratory Society Research Seminar on Preventing Pediatric Asthma

Affiliations

European Respiratory Society Research Seminar on Preventing Pediatric Asthma

Authors

Affiliations

Abstract

Conflict of interest statement

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Medical