Clinical characteristics of coronavirus disease 2019 in patients undergoing laparoscopic bariatric/metabolic surgery: a nationwide survey in Japan

Yasuhiro Miyazaki^#¹, Masayuki Ohta^#^{2

3}, Seiichi Kitahama⁴, Yosuke Seki⁵, Susumu Inamine⁶, Takashi Oshiro⁷, Yoshihiro Nagao⁸, Fumihiko Hatao⁹, Hajime Orita¹⁰, Akira Sasaki¹¹, Shunsuke Kagawa¹², Tsuyoshi Yamaguchi¹³, Keiji Aizu¹⁴, Keiji Hayata¹⁵, Shin Saito¹⁶, Manabu Amiki¹⁷, Yoji Nakamura¹⁸, Hisahiro Matsubara¹⁹, Mitsuo Shimada²⁰, Takeshi Naitoh²¹, Nobuya Ishibashi²², Shuji Takiguchi²³, Kazunori Shibao²⁴, Kentaro Inoue²⁵, Takeshi Togawa²⁶, Takuro Saito²⁷, Kohei Uno²⁸, Yuichi Endo³, Kazunori Kasama⁵, Ichiro Tatsuno²⁹

Affiliations

¹ Department of Surgery, Osaka General Medical Center, 3-1-56 Bandaihigashi, Sumiyoshi-ku, Osaka-shi, Osaka, 558-8558, Japan. ymiyazaki02@gh.opho.jp.
² Research Center for GLOBAL and LOCAL Infectious Diseases, Oita University, Oita, Japan.
³ Department of Gastroenterological and Pediatric Surgery, Oita University Faculty of Medicine, Oita, Japan.
⁴ Department of Metabolic and Bariatric Surgery, Center for Obesity, Diabetes, and Endocrinology, Chibune General Hospital, Osaka, Japan.
⁵ Weight Loss and Metabolic Surgery Center, Yotsuya Medical Cube, Tokyo, Japan.
⁶ Bariatric and Metabolic Surgery Center, Ohama Daiichi Hospital, Naha, Japan.
⁷ Department of Surgery, Toho University Sakura Medical Center, Sakura, Japan.
⁸ Center for Integration of Advanced Medicine, Life Science and Innovative Technology, Kyushu University, Fukuoka, Japan.
⁹ Department of Surgery, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan.
¹⁰ Department of Upper Gastrointestinal Surgery, Juntendo University School of Medicine, Tokyo, Japan.
¹¹ Department of Surgery, School of Medicine, Iwate Medical University, Yahaba, Japan.
¹² Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
¹³ Department of Surgery, Shiga University of Medical Science, Otsu, Japan.
¹⁴ Department of Surgery, Kasugai Municipal Hospital, Kasugai, Japan.
¹⁵ Second Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan.
¹⁶ Department of Surgery, Jichi Medical University, Shimotsuke, Japan.
¹⁷ Department of Surgery, Kawasaki Saiwai Hospital, Kawasaki, Japan.
¹⁸ Department of Digestive and General Surgery, University of the Ryukyus, Okinawa, Japan.
¹⁹ Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
²⁰ Department of Surgery, Tokushima University, Tokushima, Japan.
²¹ Department of Lower Gastrointestinal Surgery, Kitasato University School of Medicine, Sagamihara, Japan.
²² Department of Surgery, Kurume University, Kurume, Japan.
²³ Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
²⁴ Department of Surgery 1, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
²⁵ Department of Surgery, Kansai Medical University, Hirakata, Japan.
²⁶ Department of Digestive Surgery, Omi Medical Center, Kusatsu, Japan.
²⁷ Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
²⁸ Department of Surgery, Jikei University School of Medicine, Tokyo, Japan.
²⁹ Chiba Prefectural University of Health and Sciences, Chiba, Japan.

^# Contributed equally.

PMID: 39625484
DOI: 10.1007/s00595-024-02967-y

Clinical characteristics of coronavirus disease 2019 in patients undergoing laparoscopic bariatric/metabolic surgery: a nationwide survey in Japan

Yasuhiro Miyazaki et al. Surg Today. 2025 May.

. 2025 May;55(5):668-675.

doi: 10.1007/s00595-024-02967-y. Epub 2024 Dec 3.

Authors

Affiliations

¹ Department of Surgery, Osaka General Medical Center, 3-1-56 Bandaihigashi, Sumiyoshi-ku, Osaka-shi, Osaka, 558-8558, Japan. ymiyazaki02@gh.opho.jp.
² Research Center for GLOBAL and LOCAL Infectious Diseases, Oita University, Oita, Japan.
³ Department of Gastroenterological and Pediatric Surgery, Oita University Faculty of Medicine, Oita, Japan.
⁴ Department of Metabolic and Bariatric Surgery, Center for Obesity, Diabetes, and Endocrinology, Chibune General Hospital, Osaka, Japan.
⁵ Weight Loss and Metabolic Surgery Center, Yotsuya Medical Cube, Tokyo, Japan.
⁶ Bariatric and Metabolic Surgery Center, Ohama Daiichi Hospital, Naha, Japan.
⁷ Department of Surgery, Toho University Sakura Medical Center, Sakura, Japan.
⁸ Center for Integration of Advanced Medicine, Life Science and Innovative Technology, Kyushu University, Fukuoka, Japan.
⁹ Department of Surgery, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan.
¹⁰ Department of Upper Gastrointestinal Surgery, Juntendo University School of Medicine, Tokyo, Japan.
¹¹ Department of Surgery, School of Medicine, Iwate Medical University, Yahaba, Japan.
¹² Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
¹³ Department of Surgery, Shiga University of Medical Science, Otsu, Japan.
¹⁴ Department of Surgery, Kasugai Municipal Hospital, Kasugai, Japan.
¹⁵ Second Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan.
¹⁶ Department of Surgery, Jichi Medical University, Shimotsuke, Japan.
¹⁷ Department of Surgery, Kawasaki Saiwai Hospital, Kawasaki, Japan.
¹⁸ Department of Digestive and General Surgery, University of the Ryukyus, Okinawa, Japan.
¹⁹ Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
²⁰ Department of Surgery, Tokushima University, Tokushima, Japan.
²¹ Department of Lower Gastrointestinal Surgery, Kitasato University School of Medicine, Sagamihara, Japan.
²² Department of Surgery, Kurume University, Kurume, Japan.
²³ Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
²⁴ Department of Surgery 1, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
²⁵ Department of Surgery, Kansai Medical University, Hirakata, Japan.
²⁶ Department of Digestive Surgery, Omi Medical Center, Kusatsu, Japan.
²⁷ Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
²⁸ Department of Surgery, Jikei University School of Medicine, Tokyo, Japan.
²⁹ Chiba Prefectural University of Health and Sciences, Chiba, Japan.

^# Contributed equally.

PMID: 39625484
DOI: 10.1007/s00595-024-02967-y

Abstract

Purpose: Bariatric/metabolic surgery has been reported to reduce the incidence of severe coronavirus disease 2019 (COVID-19); however, its ability to reduce risk is controversial. Therefore, this study aimed to elucidate the incidence and severity of COVID-19 in bariatric patients in Japan.

Methods: The first survey of patients infected with COVID-19 after bariatric/metabolic surgery until June 30, 2022, was sent to 83 Japanese institutions. A second survey was conducted in institutions that reported on COVID-19 patients. The severity of COVID-19 was compared between the general population and bariatric patients, and risk factors correlated with severity were also evaluated.

Results: Twenty-six institutions (31.3%) reported 119 patients with COVID-19 after laparoscopic bariatric/metabolic surgery. There were no severe cases or deaths; however, moderate COVID-19 (pneumonia) was significantly more common in bariatric patients than in the general population (11.4% vs. 1.3%). The risk factors for moderate COVID-19 in bariatric patients included incurable dyslipidemia and infection before the 6th wave of the pandemic.

Conclusion: In Japan, the number of moderate COVID-19 cases may be higher in bariatric patients than in the general population. This study did not show that bariatric/metabolic surgery reduces the risk of COVID-19 complications.

Keywords: Bariatric/metabolic surgery; COVID-19; Japan; Severity.

PubMed Disclaimer

Conflict of interest statement

Declarations. Ethical approval: All data collection and analyses were performed in accordance with the ethical standards of the 1964 Declaration of Helsinki, and the protocol for this research project was approved by the Ethics Committee of the Oita University Faculty of Medicine (#2417-D5).

References

1. Ohta M, Kasama K, Sasaki A, Naitoh T, Seki Y, Inamine S, et al. Current status of laparoscopic bariatric/metabolic surgery in Japan: the sixth nationwide survey by the Japan consortium of obesity and metabolic surgery. Asian J Endosc Surg. 2021;14(2):170–7. - DOI - PubMed
1. Ohta M, Ahn SM, Seki Y, Yang W, Wong SK, Udomsawaengsup S, et al. Ten years of change in bariatric/metabolic surgery in the Asia-Pacific region with COVID-19 pandemic: IFSO-APC national reports 2021. Obes Surg. 2022;32(9):2994–3004. - DOI - PubMed - PMC
1. Kurahara Y, Kobayashi T, Shintani S, Matsuda Y, Tamiya A, Sugawara R, et al. Clinical characteristics of COVID-19 in Osaka, Japan: comparison of the first-third waves with the fourth wave. Respir Investig. 2021;59(6):810–8. - DOI - PubMed - PMC
1. Kawaji H, Kishimoto N, Muguruma N, Kozai H, Horiuchi N. Risk factors related to severity in COVID-19 patients: a real-world retrospective cohort study. Intern Med. 2023;62(18):2627–34. - DOI - PubMed - PMC
1. Michalakis K, Ilias I. SARS-CoV-2 infection and obesity: common inflammatory and metabolic aspects. Diabetes Metab Syndr. 2020;14(4):469–71. - DOI - PubMed - PMC

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Clinical characteristics of coronavirus disease 2019 in patients undergoing laparoscopic bariatric/metabolic surgery: a nationwide survey in Japan

Affiliations

Clinical characteristics of coronavirus disease 2019 in patients undergoing laparoscopic bariatric/metabolic surgery: a nationwide survey in Japan

Authors

Affiliations

Abstract

Conflict of interest statement

References

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical