Covalent inhibitor engages oncogenic AKT kinase

Comment

Alex Eccleston. Nat Rev Drug Discov. 2025 Jan.

. 2025 Jan;24(1):16.

doi: 10.1038/d41573-024-00197-y.

No abstract available

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Mutant-selective AKT inhibition through lysine targeting and neo-zinc chelation.
Craven GB, Chu H, Sun JD, Carelli JD, Coyne B, Chen H, Chen Y, Ma X, Das S, Kong W, Zajdlik AD, Yang KS, Reisberg SH, Thompson PA, Lipford JR, Taunton J. Craven GB, et al. Nature. 2025 Jan;637(8044):205-214. doi: 10.1038/s41586-024-08176-4. Epub 2024 Nov 6. Nature. 2025. PMID: 39506119

1. Craven, G. B. et al. Mutant-selective AKT inhibition through lysine targeting and neo-zinc chelation. Nature https://doi.org/10.1038/s41586-024-08176-4 (2024)