Juvenile papillomatosis: A case report

Abstract

Juvenile papillomatosis (JP) is a very rare benign proliferative breast disease, especially in young women under 30 years of age. Its etiology is not clear yet. Although some patients have breast cancer in their family history, up to 10% breast cancer can develop in the follow-up of JP patients. In this pathology, which is diagnosed with biopsy, history, clinical and radiological findings help in diagnosis. In this case report, a 37-year-old patient diagnosed with JP will be discussed in the light of the literature.

Keywords: Juvenil papillomatosis; malignancy; proliferative lesion.

Figure 1. A,B. Asymmetric fibroglandular tissue density observed in the midline posterior on the right breast MLO view.

Figure 2. A,B. Doppler examination; cysts that do not show internal vascularization in heterogeneous parenchyma area at 12 o’clock in the right breast. C. The lesion is observed in medium stiffnes in elastography examination.

Figure 3. A. T2-weighted fat saturated axial MR image B. T2-weighted fat saturated sagittal MR image - Lesion with millimeter cysts approximately 2 cm from the nipple at 12 o’clock.

Figure 4. A. T1-weighted fat saturated axial MR image. B. T1-weighted post-contrast sagittal MR image - Peripheral enhancement at the lesion and adjacent non-mass segmental enhancements are observed.

Figure 5. A,B. Papilloma areas (HE x 40) characterized by papilla-like structures in the ductus lumens within the breast parenchyma (HE x 40). C. Atypical epithelial hyperplasia areas (HE x 40).

Figure 6. Sclerosing adenosis areas (HE x 40). B. Cystic enlarged ducts (HE x 40). C. Immunhistochemical calponin positivity around the ducts (HE x 40).