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Review
. 2024 Dec 2:37:e1838.
doi: 10.1590/0102-6720202400044e1838. eCollection 2024.

THE GROWING EVIDENCE OF THE RELATIONSHIP BETWEEN OBESITY AND CANCER AND THE ROLE OF BARIATRIC SURGERY

Paulo Kassab  1 , Álvaro Antônio Bandeira Ferraz  2 , Anna Clara Hebling Mitidieri  3 , Luiz Vicente Berti  3 , Marco Aurélio Santo  4 , Tiago Szego  5 , Caio de Carvalho Zanon  1 , Osvaldo Antônio Prado Castro  1 , Wilson Rodrigues de Freitas Junior  1 , Elias Jirjoss Ilias  1 , Carlos Alberto Malheiros  1 , Antônio Carlos Valez  6 , Antônio Carlos Ligocki Campos  7 ; Brazilian College of Digestive Surgery (CBCD) and Brazilian Society of Bariatric and Metabolic Surgery (SBCBM).
Affiliations
Review

THE GROWING EVIDENCE OF THE RELATIONSHIP BETWEEN OBESITY AND CANCER AND THE ROLE OF BARIATRIC SURGERY

Paulo Kassab et al. Arq Bras Cir Dig. .

Abstract
in English, Portuguese

Obesity is recognized as a significant risk factor for various types of cancer. Although the incidence of some types of cancer across various primary sites is decreasing due to specific prevention measures (screening programs, smoking cessation), the incidence of neoplasms in the young population shows a significant increase associated with obesity. There is sufficient evidence to say that bariatric surgery has been shown to significantly lower the risk of developing obesity-associated cancers, which are linked to metabolic dysregulation, chronic low-grade systemic inflammation, and hormonal alterations such as elevated levels of insulin and sex hormones.

A obesidade é reconhecida como um fator de risco significativo para vêrios tipos de câncer. Embora a incidência de alguns tipos de câncer de vêrios locais primêrios esteja diminuindo devido a medidas específicas de prevenção (programas de triagem, cessação do tabagismo), a incidência de neoplasias na população jovem mostra um aumento significativo associado à obesidade. Hê evidências suficientes para dizer que a cirurgia bariêtrica demonstrou reduzir significativamente o risco de desenvolver cânceres associados à obesidade, que estão ligados à desregulação metabólica, inflamação sistêmica crônica de baixo grau e alterações hormonais, como níveis elevados de insulina e hormônios sexuais.

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Conflict of interest statement

Conflict of interests: None

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