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. 2024;160(3&4):371-378.
doi: 10.25259/IJMR_1014_2024.

Effect of the COVID-19 vaccination on feto-maternal outcomes: A prospective cohort study among Indian pregnant women

Aravind P Gandhi  1 , J S Thakur  2 , Madhu Gupta  2 , Kathirvel Soundappan  2 , Kapil Goel  2 , Gopal Singh  2 , Tarundeep Singh  2
Affiliations

Effect of the COVID-19 vaccination on feto-maternal outcomes: A prospective cohort study among Indian pregnant women

Aravind P Gandhi et al. Indian J Med Res. 2024.

Abstract

Background & objectives Studies on the effects of COVID-19 vaccination among pregnant women in Asian settings, more specifically in India, are scarce. The present study evaluated the feto-maternal outcomes among Indian pregnant women who received the COVID-19 vaccine. Methods A prospective cohort study was undertaken among 430 pregnant women from two primary health centres (PHC) in Chandigarh, India during 2021-2022. The feto-maternal outcomes evaluated in the study included abortions, live birth/stillbirth, term/pre-term/post-term delivery, mode of delivery (normal vaginal/caesarean section/forceps), birth weight and intrauterine growth retardation. Results Of the 430 study participants, 295 pregnant women received COVID-19 vaccines, with an uptake rate of 68.6 per cent. Majority of vaccinated women (280- who completed the study) were in their second trimester (133, 47.5%), while 92 (32.9%) were in their third, and 55 (19.6%) were in their first trimester when they were enrolled in the study. Neonatal intensive care unit (NICU) admission was significantly lower among the vaccinated pregnant women, while other feto-maternal and neonatal outcomes were similar between vaccinated and unvaccinated pregnant women. Interpretation & conclusions The findings of this study suggest COVID-19 vaccination in pregnant women in India might be safe, in terms of feto-maternal outcomes.

Keywords: COVID-19 vaccine; Covishield; India; fetal outcome; pregnancy.

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Conflict of interest statement

None.

Figures

Figure.
Figure.
Enrolment and follow up of the study participants.
See this image and copyright information in PMC

References

    1. World Health Organization Impact of vaccination on risk of COVID-19–related mortality. Available from: https://archive.cdc.gov/www_cdc_gov/coronavirus/2019-ncov/science/data-r..., accessed on October 2, 2023.
    1. Watson OJ, Barnsley G, Toor J, Hogan AB, Winskill P, Ghani AC. Global impact of the first year of COVID-19 vaccination: A mathematical modelling study. Lancet Infect Dis. 2022;22:1293–302. doi: 10.1016/S1473-3099(22)00320-6. - DOI - PMC - PubMed
    1. Rahmani K, Shavaleh R, Forouhi M, Disfani HF, Kamandi M, Oskooi RK, et al. The effectiveness of COVID-19 vaccines in reducing the incidence, hospitalization, and mortality from COVID-19: A systematic review and meta-analysis. Front Public Health. 2022;10:873596. doi: 10.3389/fpubh.2022.873596. - DOI - PMC - PubMed
    1. Moghadas SM, Vilches TN, Zhang K, Wells CR, Shoukat A, Singer BH, et al. The impact of vaccination on Coronavirus Disease 2019 (COVID-19) outbreaks in the United States. Clin Infect Dis. 2021;73:2257–64. doi: 10.1093/cid/ciab079. - DOI - PMC - PubMed
    1. World Health Organization COVID-19 advice for the public: Getting vaccinated. Available from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/covid-19..., accessed on October 29, 2024.

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