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Review
. 2024;160(3&4):338-345.
doi: 10.25259/IJMR_1478_2024.

TB-vaccines: Current status & challenges

Kuldeep Singh Sachdeva  1 , Vineet K Chadha  2
Affiliations
Review

TB-vaccines: Current status & challenges

Kuldeep Singh Sachdeva et al. Indian J Med Res. 2024.

Abstract

Tuberculosis continues to be among the leading causes of morbidity as well as mortality. It is appreciated that our aim of eliminating TB in the foreseeable future will not be realized until we have a new vaccine with significant efficacy among diverse populations and all age-groups. Although impressive strides have been made in more refined development of new TB vaccines based on learnings from past experiences, the substitute or a booster vaccine for the BCG vaccine is not available yet. This article puts in perspective the recent efforts in re-positioning BCG, development of newer vaccines based on novel approaches, the current TB vaccine pipeline, yet unmet challenges in vaccine development, exploring newer ideas in vaccine development and what the future holds.

Keywords: Adult vaccination; BCG; challenges; newer approaches; newer vaccines; pipeline; tuberculosis.

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Conflict of interest statement

None.

References

    1. World Health Organization Global Tuberculosis Report 2023. Available from: https://www.who.int/teams/global-tuberculosis-programme/tb-reports/globa..., accessed on October 28, 2024.
    1. Knowledge base for the National TB Elimination Program - NTEP Evolution of TB Programme in India. Available from: https://ntep.in/node/116/CP-evolution-tb-elimination-programme-india; accessed on November 15, 2024.
    1. Mandal S, Chadha VK, Laxminarayan R, Arinaminpathy N. Counting the lives saved by DOTS in India: A model-based approach. BMC Med. 2017;15:47. - PMC - PubMed
    1. World Health Organization End TB strategy, Global strategy and targets for tuberculosis prevention, care and control after 2015. Available from: https://cdn.who.int/media/docs/default-source/documents/tuberculosis/end..., accessed on October 20, 2024.
    1. Houben RMGJ, Menzies NA, Sumner T, Huynh GH, Arinaminpathy N, Goldhaber-Fiebert JD, et al. Feasibility of achieving the 2025 WHO global tuberculosis targets in South Africa, China, and India: A combined analysis of 11 mathematical models. Lancet Glob Health. 2016;4:e806–15. - PMC - PubMed

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