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Review
. 2024 Nov 20;3(12):101385.
doi: 10.1016/j.jacadv.2024.101385. eCollection 2024 Dec.

Spontaneous Coronary Artery Dissection: Current Knowledge, Research Gaps, and Innovative Research Initiatives: JACC Advances Expert Panel

Daniela Crousillat  1 , Amy Sarma  2 , Malissa Wood  3 , Sahar Naderi  4 , Katherine Leon  5 , C Michael Gibson  6 , Aaron Aday  7 , Anna Grodzinsky  8 , Kathy Izard  5 , Jason C Kovacic  9   10   11 , Mark E Lindsay  12 , Dermot Phelan  13 , Patricia F Rodriguez-Lozano  14 , Nandita S Scott  15 , Markus Scherer  16 , Aditya Sharma  17 , Ranya Sweis  18 , Jennifer A Sumner  19 , Esther S H Kim  20
Affiliations
Review

Spontaneous Coronary Artery Dissection: Current Knowledge, Research Gaps, and Innovative Research Initiatives: JACC Advances Expert Panel

Daniela Crousillat et al. JACC Adv. .

Abstract

Despite marked advancements in the recognition and diagnosis of spontaneous coronary artery dissection (SCAD) over the past decade, knowledge of the basic pathophysiologic mechanisms of disease, contributing factors, and treatment continue to be poorly understood. We describe significant research gaps in our knowledge of SCAD and introduce strategies including the role of patient advocacy, independent registries, and creation of diverse centers of excellence to bridge the gap in clinical care, research, and outcomes. Lastly, we introduce an innovative patient-centered clinical care and research framework established through the SCAD Alliance and International Spontaneous Coronary Artery Dissection registry as a model for advancing knowledge of SCAD.

Keywords: SCAD; health inequity; sex differences.

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Conflict of interest statement

Dr Sarma has received grants from CRICO and the 10.13039/100000968American Heart Association; and is a consultant at Pfizer. Dr Wood is a member of the Scientific Advisory Board of the SCAD Alliance. Dr Naderi is a member of the Scientific Advisory Board of the SCAD Alliance. Dr Gibson has received research support from the SCAD Alliance. Dr Aday has consulted for Merck and Janssen. Dr Lindsay is a member of the professional advisory board of the Marfan Foundation and a member of the scientific advisory board of the Myhre syndrome foundation and the ACTA2 alliance; and has received research funding from Angea Biotherapeutics. Dr Rodriguez Lozano is an iTHRIV Scholar. The iTHRIV Scholars Program is supported in part by the 10.13039/100006108National Center for Advancing Translational Sciences of the National Institutes of Health under Award Numbers UL1TR003015 and KL2TR003016. Dr Sharma is a consultant for enVVeno Corporation; is on the Speakers Bureau for Boston Scientific Corporation; and has received institutional research funding from Boston Scientific Corporation and Vascular Medcure. Dr Scott is a consultant for Mediflix. Dr Scherer is on the Speakers Bureau for Abbott, Boston Scientific, Edwards Lifesciences, HeartFlow, Philips, and Siemens. Dr Sweis is on the Speakers Bureau for Edwards Lifesciences and Medtronic; and is an editor of the Merck Manual. Dr Kim is the Chair of the Scientific Advisory Board of the SCAD Alliance. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.

Figures

None
Graphical abstract
Central Illustration
Central Illustration
Current Knowledge, Gaps, and Research Priorities in SCAD Significant knowledge gaps in our understanding of spontaneous coronary artery dissection (SCAD) and suggested future research initiatives to bridge the gaps.
Figure 1
Figure 1
Founding Principles of the iSCAD Registry iSCAD = International Spontaneous Coronary Artery Dissection.
See this image and copyright information in PMC

References

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