Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Dec 5:152:e158.
doi: 10.1017/S0950268824001134.

The predictive values of C-reactive protein-neutrophil to lymphocyte ratio for the risk of refractory Mycoplasma pneumoniae pneumonia in children: a retrospective cohort study

Xiaoli Chen  1 , Shanhu Wang  1 , Hailun Cai  1 , Xiaojiao Xia  1
Affiliations

The predictive values of C-reactive protein-neutrophil to lymphocyte ratio for the risk of refractory Mycoplasma pneumoniae pneumonia in children: a retrospective cohort study

Xiaoli Chen et al. Epidemiol Infect. .

Abstract

This cohort study evaluated the associations of C-reactive protein-neutrophil to lymphocyte ratio (C-NLR) and lymphocyte-CRP ratio (LCR) with refractory Mycoplasma pneumoniae pneumonia (RMPP), and the predictive values of C-NLR and LCR for RMPP and prolonged fever in children based on 389 children with MPP. The associations of NLR, C-NLR, and LCR with RMPP and prolonged fever were evaluated by logistic regression analysis. C-NLR was correlated with an increased risk of RMPP in children [odds ratio (OR) = 3.459, 95% confidence interval (CI): 1.598-7.491]. A higher risk of RMPP was identified in the C-NLR > 29.9 group (OR = 2.885, 95% CI: 1.599-5.203). LCR > 1584.2 was associated with a decreased risk of RMPP (OR = 0.500, 95% CI: 0.282-0.887). Increased risk of prolonged fever in children was identified with the increase of C-NLR (OR = 5.913, 95% CI: 2.335-14.972) or NLR (OR = 2.413, 95% CI: 1.689-3.446). The AUCs of C-NLR, LCR, and NLR for predicting RMPP were 0.630, 0.623, and 0.608, respectively. In conclusion, C-NLR was associated with increased RMPP risk in children and had good value for predicting RMPP and prolonged fever in children.

Keywords: C-reactive protein-neutrophil to lymphocyte ratio; lymphocyte-CRP ratio; neutrophil to lymphocyte ratio; refractory Mycoplasma pneumoniae pneumonia.

PubMed Disclaimer

Conflict of interest statement

None.

Figures

Figure 1.
Figure 1.
The flow chart of the participants screening process.
Figure 2.
Figure 2.
The ROC curve of the predictive values of NLR, C-NLR, and LCR for RMPP in children.
Figure 3.
Figure 3.
The ROC curve of the predictive values of NLR, C-NLR, and LCR for prolonged fever in children.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Che-Morales JL and Cortes-Telles A (2019) Neutrophil-to-lymphocyte ratio as a serum biomarker associated with community acquired pneumonia. Revista Médica del Instituto Mexicano del Seguro Social 56(6), 537–543. - PubMed
    1. Cheng S, Lin J, Zheng, X, Yan L, Zhang Y, Zeng Q and Dai J (2020). Development and validation of a simple-to-use nomogram for predicting refractory Mycoplasma pneumoniae pneumonia in children. Pediatric Pulmonology 55(4), 968–974. 10.1002/ppul.24684. - DOI - PubMed
    1. Ding Y, Chu C, Li Y, Li G, Lei X, Zhou W and Chen Z (2018) High expression of HMGB1 in children with refractory Mycoplasma pneumoniae pneumonia. BMC Infectious Diseases 18(1), 439. 10.1186/s12879-018-3346-8. - DOI - PMC - PubMed
    1. Fu B, Zhang P and Zhang J (2023) Diagnosis and prognosis evaluation of severe pneumonia by lung ultrasound score combined with serum inflammatory markers. Mediterranean Journal of Hematology and Infectious Disease 15(1), e2023057. 10.4084/mjhid.2023.057. - DOI - PMC - PubMed
    1. Harris M, Clark J, Coote N, Fletcher P and Thomson A (2011) British Thoracic Society guidelines for the management of community acquired pneumonia in children: update 2011. Thorax 66(Suppl 2), ii1–23. 10.1136/thoraxjnl-2011-200598. - DOI - PubMed

Substances