Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Dec 5:152:e157.
doi: 10.1017/S0950268824001535.

Global epidemiology of serogroup Y invasive meningococcal disease: a literature review

Myint Tin Tin Htar  1 , Jamie Findlow  2 , Paul Balmer  3 , David Swerdlow  3
Affiliations

Global epidemiology of serogroup Y invasive meningococcal disease: a literature review

Myint Tin Tin Htar et al. Epidemiol Infect. .

Abstract

Serogroup epidemiology of invasive meningococcal disease (IMD) is constantly evolving, varying by time and location. Surveillance reports have indicated a rise in meningococcal serogroup Y (MenY) in some regions in recent years. This systematic literature review explores the evolving epidemiology of MenY IMD globally based on review of recent articles and national surveillance reports published between 1 January 2010 and 25 March 2021. Generally, MenY incidence was low (<0.2/100,000) across all ages in most countries. The reported incidence was more frequent among infants, adolescents, and those aged ≥65 years. More than 10% of all IMD cases were MenY in some locations and time periods. Implementation of vaccination evolved over time as the rise in MenY IMD percentage occurred. Cases decreased in countries with quadrivalent vaccine programs (e.g., United Kingdom, the Netherlands, United States, and Australia), whereas the MenY burden increased and made up a large proportion of cases in areas without vaccine programs. Continuous monitoring of epidemiologic changes of IMD is essential to establish MenY burden and for implementation of prevention strategies.

Keywords: bacteria; clinical manifestiations; infectious disease; meningococcal; serogroups; vaccine.

PubMed Disclaimer

Conflict of interest statement

M.T.T.H., J.F., and P.B. are employees of Pfizer Inc. and may hold stock or stock options. D.S. is a former employee of Pfizer Inc. and may hold stock or stock options.

Figures

Figure 1.
Figure 1.
Flowchart of included literature. ECDC, European Centre for Disease Prevention and Control; IMD, invasive meningococcal disease; WHO, World Health Organization.
Figure 2.
Figure 2.
Number of MenY IMD cases in Australia by age group [12]. IMD, invasive meningococcal disease; MenY, meningococcal serogroup Y.
Figure 3.
Figure 3.
Percentage of IMD cases due to MenY overall (a) and incidence of MenY by age group in the European Union/European Economic Area (b) [10]. MenY, meningococcal serogroup Y.
Figure 4.
Figure 4.
Number of MenY IMD cases by age group in (a) selected countries in Latin America [36] and (b) the United States [19]. IMD, invasive meningococcal disease; MenY, meningococcal serogroup Y.
See this image and copyright information in PMC

References

    1. Nadel S and Ninis N (2018) Invasive meningococcal disease in the vaccine era. Frontiers in Pediatrics 6, 321. - PMC - PubMed
    1. World Health Organization. Meningitis (2023). Available at http://www.who.int/en/news-room/fact-sheets/detail/meningococcal-meningitis (accessed 22 November 2024).
    1. Rouphael NG and Stephens DS (2012) Neisseria meningitidis: Biology, microbiology, and epidemiology. Methods in Molecular Biology 799, 1–20. - PMC - PubMed
    1. Peterson ME, et al. (2019) Meningococcal serogroups and surveillance: A systematic review and survey. Journal of Global Health 9, 010409. - PMC - PubMed
    1. Pelton SI (2016) The global evolution of meningococcal epidemiology following the introduction of meningococcal vaccines. Journal of Adolescent Health 59, S3–S11. - PubMed

Publication types

Substances