Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Dec 5;317(1):66.
doi: 10.1007/s00403-024-03560-6.

Experience of negative pressure fractional microneedle radiofrequency therapy for axillary osmidrosis: a case study

Yuping Zhang #  1 , Yirong Li #  1   2 , Chen Li  1 , Ju Tian  3
Affiliations

Experience of negative pressure fractional microneedle radiofrequency therapy for axillary osmidrosis: a case study

Yuping Zhang et al. Arch Dermatol Res. .

Abstract

Background: Negative pressure fractional microneedle radiofrequency (NPFMR) therapy has emerged as a potential minimally invasive treatment for axillary osmidrosis (AO), a condition characterized by persistent strong body odor from the armpit area.

Methods: This case study aims to assess the efficacy and safety of NPFMR for AO treatment. From January to September 2024, 30 patients with AO were recruited, with a gender distribution of 19 females and 11 males, aged 17-34 years (mean 23). AO was diagnosed based on the presence of strong armpit odor in the absence of significant hyperhidrosis. The severity of AO was classified into four grades. All patients were followed up at 3 months, 6 months and 1 year post-treatment. The efficacy and complications were recorded and assessed.

Results: The efficacy rates observed at 3 months and 6 months post-treatment were 83.67% and 76.67% respectively, with the efficacy rate remaining the same as that at 6 months after 1 year of follow-up. There were four cases of complications, At the 3-month follow-up, three patients developed punctate scars in the treated area, with the largest scar measuring 0.5 cm in diameter. One patient reported a numbness in their upper limb at the 3-month follow-up, which resolved after oral administration of mecobalamin at the 6-month follow-up. The total complication rate for this group was 13.3%.

Conclusion: NPFMR therapy demonstrates promising short-term efficacy for AO treatment. However, caution should be exercised due to potential complications, and comprehensive patient education is necessary. Longer-term follow-up studies are needed to evaluate the durability of the therapeutic effects and to monitor for any delayed adverse effects. Strategies for managing complications should also be explored to improve patient care outcomes.

Keywords: Axillary bromidrosis; Axillary hyperhidrosis; Axillary osmidrosis; Fractional microneedle radiofrequency.

PubMed Disclaimer

Conflict of interest statement

Declarations. Conflict of interest: The authors hereby declare that they have no financial or personal interests that could pose a conflict of interest in relation to the content of this manuscript. Informed consent for publication: The study was conducted in compliance with the ethical principles outlined in the 1975 Declaration of Helsinki. All participants provided voluntary, informed consent prior to undergoing any study-related procedures, assessments, or treatments. Furthermore, written consent for the publication of any patient images or clinical information was prospectively obtained from the respective patients or, in cases where patients were minors or unable to provide consent, from their legal representatives.

Similar articles

See all similar articles

References

    1. Li H, Qin G, Zhang J et al (2022) Axillary fossaa microbial dysbiosis and its relationship with axillary osmidrosis patients. Microb Pathogenesis 173(Pt A):105886. https://doi.org/10.1016/j.micpath.2022.105886 - DOI
    1. Toyoda Y, Takada T, Gomi T et al (2017) Clinical and molecular evidence of ABCC11 protein expression in axillary apocrine glands of patients with axillary osmidrosis. Int J Mol Sci. https://doi.org/10.3390/ijms18020417 - DOI - PubMed - PMC
    1. Malik AS, Porter CL, Feldman SR (2021) Bromhidrosis treatment modalities: a literature review. J Am Acad Dermatol 89(1):81–89. https://doi.org/10.1016/j.jaad.2021.01.030 - DOI - PubMed
    1. Morioka D, Nomura M, Lan L et al (2020) Axillary osmidrosis: past, present, and future. Ann Plas Surg 84(6):722–728. https://doi.org/10.1097/SAP.0000000000002111 - DOI
    1. Asilian A, Shahbazi M, Abtahi-Naeini B et al (2018) Percutaneous ethanol injection as a promising and minimally invasive treatment for axillary osmidrosis: double-blinded randomized controlled trial. Indian J Dermatol Ve 84(2):157–162. https://doi.org/10.4103/ijdvl.IJDVL_704_16 - DOI

LinkOut - more resources