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Editorial
. 2024 Dec 6;135(12):1138-1140.
doi: 10.1161/CIRCRESAHA.124.325719. Epub 2024 Dec 5.

Salt's Sex-Specific Impact of Gut Microbiota in Hypertension

Selam Desta  1 , Claude F Albritton  1   2 , Annet Kirabo  1   3   4   5
Affiliations
Editorial

Salt's Sex-Specific Impact of Gut Microbiota in Hypertension

Selam Desta et al. Circ Res. .
No abstract available

Keywords: Editorials; blood pressure; cardiovascular diseases; dysbiosis; hypertension.

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Conflict of interest statement

None.

Figures

Figure.
Figure.. ACE2 sex-specific expression modulates gut microbiota responses in salt-sensitive hypertension
Male ACE2 deficient rats demonstrated an increased prohypertensive phenotype which was characterized by multiple parameters. Male ACE2 −/− rats exhibited increased intestinal expression of IL-1β and IL-17RC, increased Escherichia/Shigella abundance, increased Trp and Indole levels, and increased expression of multiple E.coli-derived tryptophanase A genes. Female ACE2 −/− exhibited exclusively heightened expression of E.coli K12 (MG1655) tryptophanase A. Beta diversity alterations were observed in both sexes. Interestingly, female heterozygous ACE2 −/+ rats exhibited decreased IL-17RC and indole when compared to female ACE2 deficient mice suggesting a protective effect derived from one allele. This protective role was further substantiated by the lower BP exhibited in female ACE2 −/+ and non-differential body weight between ACE2 −/+ and NF female rats.
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Comment on

References

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