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Comment
. 2024 Dec 6;386(6726):1094-1095.
doi: 10.1126/science.adt9921. Epub 2024 Dec 5.

Synthetic gene circuits drive disease-fighting T cells

Marco L Davila  1 , Renier Brentjens  1
Affiliations
Comment

Synthetic gene circuits drive disease-fighting T cells

Marco L Davila et al. Science. .

Abstract

Immune cells can be programmed to deliver targeted therapies in models of brain and inflammatory disease.

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Comment on

  • Programming tissue-sensing T cells that deliver therapies to the brain.
    Simic MS, Watchmaker PB, Gupta S, Wang Y, Sagan SA, Duecker J, Shepherd C, Diebold D, Pineo-Cavanaugh P, Haegelin J, Zhu R, Ng B, Yu W, Tonai Y, Cardarelli L, Reddy NR, Sidhu SS, Troyanskaya O, Hauser SL, Wilson MR, Zamvil SS, Okada H, Lim WA. Simic MS, et al. Science. 2024 Dec 6;386(6726):eadl4237. doi: 10.1126/science.adl4237. Epub 2024 Dec 6. Science. 2024. PMID: 39636984 Free PMC article.
  • Engineering synthetic suppressor T cells that execute locally targeted immunoprotective programs.
    Reddy NR, Maachi H, Xiao Y, Simic MS, Yu W, Tonai Y, Cabanillas DA, Serrano-Wu E, Pauerstein PT, Tamaki W, Allen GM, Parent AV, Hebrok M, Lim WA. Reddy NR, et al. Science. 2024 Dec 6;386(6726):eadl4793. doi: 10.1126/science.adl4793. Epub 2024 Dec 6. Science. 2024. PMID: 39636990 Free PMC article.

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