Review
Jasper's Basic Mechanisms of the Epilepsies
5th edition. New York: Oxford University Press; 2024.
Affiliations
- PMID: 39637091
- Bookshelf ID: NBK609907
- DOI: 10.1093/med/9780197549469.001.0001
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Review
Jasper's Basic Mechanisms of the Epilepsies
Excerpt
This resource, considered the 'bible' of basic epilepsy research, offers encyclopedic coverage and in depth discussions of leading research hypotheses and strategic approaches. Indispensable for students and all research scientists in the field of epilepsy research, and now of practical importance to the clinic, it also maps out new research directions for the next decade.
Sections
- Copyright Page
- Dedication
- Preface
- Jasper’s Basic Mechanisms of the Epilepsies Workshops Yosemite National Park, March 4–8, 2019
- Acknowledgments
- Contributors
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Section 1. Evolving Concepts
- 1. The Paroxysmal Depolarizing Shift: The First Cellular Marker of Focal Epileptogenesis
- 2. Hippocampal Sclerosis in Temporal Lobe Epilepsy: New Views and Challenges
- 3. Cerebral Cortical Dysplasia or Dysgenesis: Keratan Sulfate Proteoglycan for Fetal Axonal Guidance and Excitatory/Inhibitory Synaptic Targets That Influence Epileptogenesis
- 4. mTOR in Acquired and Genetic Models of Epilepsy
- 5. Epilepsy Genomics: Disease-Causing Sequence Variants
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Section 2. Seizures, Networks, and Systems
- 6. GABAA-Receptor Signaling and Ionic Plasticity in the Generation and Spread of Seizures
- 7. Connexins, Pannexins, and Epilepsy
- 8. Mechanisms Leading to Initiation, Development, and Termination of Focal Seizures
- 9. Transition to Seizure from Cellular, Network, and Dynamical Perspectives
- 10. Role of the Subiculum in Focal Epilepsy
- 11. Optogenetic Modulation of Focal Seizures
- 12. Balancing Seizure Control with Cognitive Side Effects Using Changes in Theta
- 13. High-Frequency Oscillations
- 14. Seizures and Sleep
- 15. Cycles in Epilepsy
- 16. Human Single-Neuron Recordings in Epilepsy
- 17. Role of Ion Concentration Dynamics in Epileptic Seizures
- 18. A Classification of Seizures Based on Dynamics
- 19. Computational EEG Analysis of Human Epileptogenic Networks
- 20. Excitation-Inhibition Balance in Absence Seizure Ictogenesis
- 21. Cortical and Thalamic PV+ Interneuron Dysfunction in the Pathogenesis of Absence Epilepsy
- 22. Convergence of Thalamic Mechanisms in Genetic Epilepsies
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Section 3. Epileptogenesis: Molecular Mechanism and Treatments
- 23. The Diverse Roles of Mossy Cells in the Normal Brain, Epileptogenesis, and Chronic Epilepsy
- 24. Temporal Lobe Epileptogenesis: A Focus on Etiology, Neuron Loss, the Latent Period, and Dentate Granule Cell Disinhibition
- 25. Adult Neurogenesis in Epileptogenesis and Comorbidities
- 26. A Crucial Role for Astrocytes in Epileptogenesis: Gap Junctions and Glutamate Receptors
- 27. Adenosine Kinase: Cytoplasmic and Nuclear Isoforms
- 28. Inflammatory Astrocytic TGFβ Signaling Induced by Blood–Brain Barrier Dysfunction Drives Epileptogenesis
- 29. Pericytes and Microglia: Neurovascular and Immune Regulatory Cells in Seizure Disorders
- 30. Neuroinflammation in Epilepsy: Cellular and Molecular Mechanisms
- 31. Role of Reactive Oxygen Species in Epilepsy
- 32. BDNF/TrkB Signaling and Epileptogenesis
- 33. Clinical Features and Molecular Mechanisms Underlying Autoantibody-Mediated Seizures
- 34. Transcriptomic Alterations in Epileptogenesis: Transcription Factors in the Spotlight
- 35. Epigenetics
- Section 4. Biomarkers of Epileptogenesis
-
Section 5. Genes and Network Development
- 41. Human Epilepsy Gene Discovery: The Next Decade
- 42. Functional Exploration of Epilepsy Genes in Patient-Derived Cells
- 43. Brain Mosaicism in Epileptogenic Cortical Malformations
- 44. Sodium Channelopathies in Human and Animal Models of Epilepsy and Neurodevelopmental Disorders
- 45. Potassium Channels in Genetic Epilepsy: A Functional Perspective
- 46. High-Voltage-Activated Calcium Channels in Epilepsy: Lessons from Humans and Rodents
- 47. Transcriptional Regulation of Cortical Interneuron Development
- 48. GABAA Receptors, Seizures, and Epilepsy
- 49. Gene–Genome Interactions: Understanding Complex Molecular Traits in Epilepsy
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Section 6. Progressive Myoclonus Epilepsies
- 50. The Neuronal Ceroid Lipofuscinoses
- 51. Progressive Myoclonus Epilepsy: Unverricht-Lundborg Disease
- 52. Strategies on Gene Therapy in Progressive Myoclonus Epilepsies
- 53. Therapeutic Window for the Treatment of Lafora Disease
- 54. Progressive Myoclonus Epilepsy of Lafora: Treatment with Metformin
- 55. Treating Lafora Disease with an Antibody-Enzyme Fusion
- 56. Antisense Oligonucleotide Therapy for Progressive Myoclonus Epilepsies
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Section 7. Comorbidities of Epileptic Networks
- 57. Dissecting Epileptic and Cognitive Network Dysfunction in Epilepsy
- 58. Attention-Deficit Disorders and Epilepsy
- 59. What Rodent Models Teach Us about the Association of Autism and Epilepsy
- 60. Artificial Intelligence–Guided Behavioral Phenotyping in Epilepsy
- 61. Mechanisms of Depression in the Epileptic Brain
- 62. Heterogeneous Mechanisms of Spreading Depolarization and Seizures
- 63. Genetic and Cellular Mechanisms Underlying SUDEP Risk
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Section 8. Epilepsy Therapeutics
- 64. New Models for Assessment of Antiseizure Activity
- 65. Disease Biology Factors Accounting for Epilepsy Severity: An Updated Conceptual Framework for New Drug Discovery
- 66. Animal Models of Pharmacoresistant Epilepsy
- 67. Drug Combinations for Antiepileptogenesis
- 68. Prophylaxis of Epileptogenesis in Injury and Genetic Epilepsy Models
- 69. Management of Febrile Status Epilepticus: Past, Present, and Future
- 70. Excitatory Transmission in Status Epilepticus
- 71. Ionic Mechanisms of Ictogenic Disinhibition: All GABA Signaling Is Local
- 72. Epileptogenic Channelopathies Guide Design of NBI-921352, a Highly Isoform-Selective Inhibitor of NaV1.6
- 73. Purinergic Signaling in Epilepsy
- 74. Anti-inflammatory Strategies for Disease Modification: Focus on Therapies Close to Clinical Translation
- 75. Targeted Augmentation of Nuclear Gene Output (TANGO)
- 76. Gene Therapy for Epilepsy
- 77. Gene Therapy for Refractory Epilepsy
- 78. Cell Therapy for Treatment of Epilepsy
- 79. Mechanisms of Ketogenic Diet Action
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