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Review
. 2025 Jan:59:101098.
doi: 10.1016/j.neo.2024.101098. Epub 2024 Dec 4.

Pediatric neuro-oncology: Highlights of the last quarter-century

Phoebe Power  1 , Joelle P Straehla  2 , Jason Fangusaro  3 , Pratiti Bandopadhayay  4 , Neevika Manoharan  5
Affiliations
Review

Pediatric neuro-oncology: Highlights of the last quarter-century

Phoebe Power et al. Neoplasia. 2025 Jan.

Abstract

The last quarter century has heralded dramatic changes in the field of pediatric neuro-oncology, with the era defined by profound developments in the understanding of the biological underpinnings of childhood central nervous system (CNS) tumors and translational therapeutics. Although there have been momentous strides forward in biologic, diagnostic, therapeutic, and experimental domains, considerable challenges remain and CNS tumors remain the leading cause of pediatric cancer-related mortality. Here, we review the significant advances in the field of pediatric neuro-oncology over the last 25 years and highlight ongoing hurdles facing future progress.

Keywords: DMG; Immunotherapy; Medulloblastoma; Pediatric neuro-oncology; Targeted therapy; pLGG.

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Conflict of interest statement

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Jason Fangusaro serves on the Educational Speaker's Bureau for Day One Biopharmaceuticals. Pratiti Bandopadhayay has served on paid advisory boards for QED Therapeutics and Day One Biopharmaceuticals, and she currently serves on the Board of the Justice Resource Institute as a Trustee. Her laboratory has also received grant funding from the Novartis Institute of Biomedical Research.

Figures

Fig 1
Fig. 1
Key advancements in pediatric neuro-oncology over the last quarter-century. A representative schematic highlighting the major areas of development, including biological, diagnostic and therapeutic advances.
See this image and copyright information in PMC

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