Declaration of competing interest Dr. Strom reports grant funding from the National Institutes of Health (1R01HL169517, 1R01AG063937), Anumana, Bracco Diagnostics, and Philips Healthcare, consulting for Bracco Diagnostics, Edwards Lifesciences, General Electric Healthcare, Philips Healthcare, EVERSANA Lifesciences, and Bristol Myers Squibb. Dr. Strom additionally reports scientific advisory board roles for Ultromics, HeartSciences, and EchoIQ, and is on a clinical end point committee for Pfizer. Dr. Grayburn reports grant funding from National Institutes of Health, Abbott Vascular, Boston Scientific, Cardiovalve, CardioMech, Edwards Lifesciences, Medtronic, Restore Medical, and 4C Medical and being on consulting/advisory boards for Abbott Vascular, Edwards Lifesciences, Medtronic, and 4C Medical. The remaining authors have no competing interests to declare.