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Case Reports
. 2025 May 19;101(4):278-279.
doi: 10.1136/sextrans-2024-056367.

Interesting case of syphilis with atypical vegetative lesions

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Case Reports

Interesting case of syphilis with atypical vegetative lesions

Luca Pipitò et al. Sex Transm Infect. .

Abstract

Syphilis is a re-emerging disease, and suspicion of syphilis infection should be considered in all cases with atypical skin manifestations, mainly when there is a history of unprotected sexual intercourse. Here, we describe a case of secondary syphilis in a woman aged 42 years, who presented with an atypical, painful and itchy skin rash with vegetative cerebriform lesions, which resolved after the administration of penicillin. Multiplex PCR targeting Treponema pallidum on vaginal and lesion swabs, along with syphilis serology, confirmed the diagnosis.

Keywords: molecular diagnostic techniques; sexual behavior; syphilis.

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Conflict of interest statement

Competing interests: None declared.

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