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Review
. 2025 Mar;39(1):121-144.
doi: 10.1016/j.idc.2024.11.008. Epub 2024 Dec 4.

Mucormycosis

Mary M Czech  1 , Jennifer Cuellar-Rodriguez  2
Affiliations
Review

Mucormycosis

Mary M Czech et al. Infect Dis Clin North Am. 2025 Mar.

Abstract

Mucormycosis is an aggressive and frequently lethal disease. Most patients with mucormycosis have poorly controlled diabetes mellitus and rhino-orbito-cerebral disease. Patients with hematologic malignancy and transplant recipients mostly present with rhino-orbito-cerebral or pulmonary disease. Prompt recognition of clinical symptoms and radiographic features of mucormycosis is required to establish timely diagnosis and initiate targeted therapy. Diagnosis is, historically, made by direct microscopy, culture, and pathology of biopsy tissue, but molecular methods are increasingly playing a role in establishing an earlier diagnosis. Treatment is multidisciplinary, involving early surgical intervention, antifungal therapy, and correction of underlying immune compromising risk factors when possible.

Keywords: Amphotericin; Diabetes; Isavuconazole; Mucormycosis; Posaconazole.

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Conflict of interest statement

Disclosure The authors have nothing to disclose.

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