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Review
. 2025 Aug;36(8):710-720.
doi: 10.1016/j.tem.2024.11.005. Epub 2024 Dec 4.

Rewiring of the glymphatic landscape in metabolic disorders

Bandy Chen  1 , David Meseguer  2 , Stephanie Lenck  3 , Jean-Leon Thomas  4 , Marc Schneeberger  5
Affiliations
Review

Rewiring of the glymphatic landscape in metabolic disorders

Bandy Chen et al. Trends Endocrinol Metab. 2025 Aug.

Abstract

The incorporation of the glymphatic clearance system in the study of brain physiology aids in the advancement of innovative diagnostic and treatment strategies for neurological disorders. Exploring the glymphatic system across (from) neurological and (to) metabolic diseases may provide a better link between obesity and neurological disorders. Recent studies indicate the role of metabolic dysfunction as a risk factor for cognitive decline and neurological disorders through the disruption of the glymphatic system. Further investigation into how metabolic dysfunction disrupts glymphatic homeostasis and the domino effects on the neurovascular landscape, including neurovascular uncoupling, cerebral blood flow disruptions, blood-brain barrier leakage, and demyelination, can provide mechanistic insights into the link between obesity and neurological disorders.

Keywords: cerebral blood flow; cerebrospinal fluid; glymphatic system; metabolic syndrome; neurodegeneration; obesity.

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Conflict of interest statement

Declaration of interests No interests are declared.

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