Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Jan 1;39(1):95-98.
doi: 10.1097/QAD.0000000000004040. Epub 2024 Dec 5.

Proviral HIV DNA sequencing to inform suitability for long-acting injectable cabotegravir/rilpivirine

Jasmini Alagaratnam  1   2 , Niall Kelly  2 , Simon Dustan  2 , Nadia Naous  1 , Modest Nwanbila  1 , Ruth Byrne  1 , Nicolo Girometti  1 , David Asboe  1 , Graham P Taylor  2   3 , Marta Boffito  1   2
Affiliations

Proviral HIV DNA sequencing to inform suitability for long-acting injectable cabotegravir/rilpivirine

Jasmini Alagaratnam et al. AIDS. .

Abstract

Increasingly, people attending HIV services are requesting long-acting injectable (LAI) antiretroviral treatment (ART). However, without HIV RNA resistance-associated mutation results, individuals are considered unsuitable for LAI ART. We present our experience of sequencing proviral HIV DNA in 30 individuals to inform suitability for LAI ART, of whom 23 were considered suitable. In conclusion, optimization of diagnostic tools such as proviral HIV DNA sequencing to confirm suitability for LAI ART would be a welcome addition.

PubMed Disclaimer

Conflict of interest statement

J.A. has received support to attend scientific conferences and has research grant funding from Gilead Sciences and has received speaker's fees from Merck Sharp & Dohme and Gilead Sciences. M.B. has received travel and research grants from and has been advisor/speaker for Janssen, Roche, ViiV, GSK, Merck Sharp & Dohme, Gilead, Pfizer, AZ, Moderna, and Sanofi. For the remaining authors, none were declared.

References

    1. NICE. Cabotegravir with rilpivirine for treating HIV-1: technology appraisal guidance. Published Online: 5 January 2022. https://www.nice.org.uk/guidance/ta757/resources/cabotegravir-with-rilpi.... [Accessed 26 May 2024].
    1. EMC. Vocabria. https://www.medicines.org.uk/emc/product/12957/smpc#gref. [Accessed 12 October 2024].
    1. EMC. Rekambys. https://www.medicines.org.uk/emc/product/12950. [Accessed 12 October 2024].
    1. Organization WH. WHO | Consolidated guidelines on HIV prevention, diagnosis, treatment and care for key populations. WHO Published Online First: 2021. http://www.who.int/hiv/pub/guidelines/keypopulations/en/. [Accessed 10 April 2021].
    1. Panel on Antiretroviral Guidelines for Adults N-. Guidelines for the use of antiretroviral agents in adults and adolescents with HIV. Dep Heal Hum Serv 2022. https://clinicalinfo.hiv.gov/. [Accessed 1 October 2022].

MeSH terms