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Comment
. 2025 Jan;103(1):9-11.
doi: 10.1111/imcb.12842. Epub 2024 Dec 6.

ILC1 as critical gatekeepers in autoimmune kidney damage

Cyril Seillet  1   2 , Le Xiong  1   2
Affiliations
Comment

ILC1 as critical gatekeepers in autoimmune kidney damage

Cyril Seillet et al. Immunol Cell Biol. 2025 Jan.

Abstract

A recent article has shown that blocking NKp46 signaling reduces injury, highlighting these cells as key drivers of organ damage and potential therapeutic targets in autoimmune diseases. In lupus nephritis, NKp46+ ILC1s orchestrate kidney inflammation by producing CSF2, driving the expansion of pro-inflammatory macrophages that infiltrate epithelial niches and exacerbate tissue damage.

Keywords: inflammation; innate lymphoid cells; systemic lupus erythematosus (SLE).

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Comment on

  • Amplification of autoimmune organ damage by NKp46-activated ILC1s.
    Biniaris-Georgallis SI, Aschman T, Stergioula K, Schreiber F, Jafari V, Taranko A, Karmalkar T, Kasapi A, Lenac Rovis T, Jelencic V, Bejarano DA, Fabry L, Papacharalampous M, Mattiola I, Molgora M, Hou J, Hublitz KW, Heinrich F, Guerra GM, Durek P, Patone G, Lindberg EL, Maatz H, Hölsken O, Krönke G, Mortha A, Voll RE, Clarke AJ, Hauser AE, Colonna M, Thurley K, Schlitzer A, Schneider C, Stamatiades EG, Mashreghi MF, Jonjic S, Hübner N, Diefenbach A, Kanda M, Triantafyllopoulou A. Biniaris-Georgallis SI, et al. Nature. 2024 Oct;634(8035):952-960. doi: 10.1038/s41586-024-07907-x. Epub 2024 Aug 13. Nature. 2024. PMID: 39137897

References

REFERENCES

    1. Biniaris‐Georgallis SI, Aschman T, Stergioula K, et al. Amplification of autoimmune organ damage by NKp46‐activated ILC1s. Nature 2024; 634: 952–960.
    1. Tang PM, Nikolic‐Paterson DJ, Lan HY. Macrophages: versatile players in renal inflammation and fibrosis. Nat Rev Nephrol 2019; 15: 144–158.
    1. Guo C, Zhou M, Zhao S, et al. Innate lymphoid cell disturbance with increase in ILC1 in systemic lupus erythematosus. Clin Immunol 2019; 202: 49–58.
    1. Narni‐Mancinelli E, Gauthier L, Baratin M, et al. Complement factor P is a ligand for the natural killer cell‐activating receptor NKp46. Sci Immunol 2017; 2: eaam9628.
    1. Vivier E, Artis D, Colonna M, et al. Innate lymphoid cells: 10 years on. Cell 2018; 174: 1054–1066.

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