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. 2025 Jan:180:106327.
doi: 10.1016/j.fitote.2024.106327. Epub 2024 Dec 4.

Two new sesquiterpenol caffeates from Bauhinia brychycarpa Wall. ex Benth. and their α-glucosidase inhibitory activity

Xingping Zhang  1 , Wenjie Ma  2 , Kepu Huang  1 , Congxi Gao  1 , Xiaoxue Jiang  1 , Mingming Li  3 , Kou Wang  4
Affiliations

Two new sesquiterpenol caffeates from Bauhinia brychycarpa Wall. ex Benth. and their α-glucosidase inhibitory activity

Xingping Zhang et al. Fitoterapia. 2025 Jan.

Abstract

Two new sesquiterpenol caffeates, bausesquitate A (1) and bausesquitate B (2), were isolated from the stems and leaves of Bauhinia brychycarpa. Structures of two compounds were confirmed by UV, IR, HR-ESI-MS, 1D and 2D NMR, ECD spectra and DP4+ probability analysis. In vitro, compounds 1 and 2 showed better inhibitory effect on α-glucosidase than acarbose (IC50 = 280.50 ± 6.27 μM) with the IC50 values of 1.81 ± 0.12 μM and 3.79 ± 0.27 μM. Additionally, molecular docking and molecular dynamics simulation were performed to analyze the potential binding sites.

Keywords: Bauhinia brychycarpa Wall. ex Benth.; DP4+; ECD calculation; Sesquiterpenol caffeate; α-Glucosidase inhibitory activity.

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Conflict of interest statement

Declaration of competing interest The authors declare no competing financial interest.

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