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Review
. 2025 Jun;50(6):2522-2532.
doi: 10.1007/s00261-024-04732-8. Epub 2024 Dec 4.

Classification of intrahepatic cholangiocarcinoma

Maria El Homsi  1 , Ahmad Alkhasawneh  2 , Hina Arif-Tiwari  3 , Ferenc Czeyda-Pommersheim  4 , Hala Khasawneh  5 , Andrea Siobhan Kierans  6 , Raj Mohan Paspulati  7 , Charanjeet Singh  4
Affiliations
Review

Classification of intrahepatic cholangiocarcinoma

Maria El Homsi et al. Abdom Radiol (NY). 2025 Jun.

Abstract

Cholangiocarcinoma is a heterogenous malignancy with various classifications based on location, morphological features, histological features, and actionable genetic mutations. Intrahepatic cholangiocarcinoma (ICC), which arises in and proximal to second order bile ducts, is the second most common primary liver malignancy after hepatocellular carcinoma. In this review, we will discuss ICC risk factors, precursor lesions, various growth, anatomic, morphologic, and histologic classifications, rare variants, and differential diagnoses.

Keywords: Hepatobiliary agent; Intrahepatic cholangiocarcinoma; MRI; Mass forming cholangiocarcinoma.

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Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests.

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