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Case Reports
. 2025 Feb;31(2):242-245.
doi: 10.1177/13524585241303479. Epub 2024 Dec 7.

Ofatumumab-associated colitis: A case report

Ashish D Patel  1 , Alexa Connors  1 , Megan E Esch  1
Affiliations
Case Reports

Ofatumumab-associated colitis: A case report

Ashish D Patel et al. Mult Scler. 2025 Feb.

Abstract

Background: Colitis has been reported with some anti-CD20 therapies in multiple sclerosis (MS), but not previously with ofatumumab.

Objectives: To report the first case of ofatumumab-associated colitis in MS and discuss its implications.

Methods: Case report.

Results: A 56-year-old female with relapsing-remitting multiple sclerosis (RRMS) developed severe colitis 3 months after initiating ofatumumab, requiring hospitalization and treatment discontinuation.

Conclusion: This case suggests a potential class effect of anti-CD20 therapies, including ofatumumab, in relation to colitis in MS. Clinicians should monitor for gastrointestinal symptoms in MS patients receiving any anti-CD20 therapy.

Keywords: Ofatumumab; adverse effect; anti-CD20 therapy; colitis; inflammatory bowel disease; multiple sclerosis.

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Conflict of interest statement

Declaration of Conflicting InterestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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