Understanding and overcoming the pitfalls in the diagnosis of pleomorphic and carcinoma ex-pleomorphic adenoma of salivary glands

Ziyad Alsugair¹, Charles Lépine², Maxime Fieux^{3

4}, Françoise Descotes⁵, Daniel Pissaloux^{6

7}, Jonathan Lopez^{4

5}, Juliette Russel⁶, Philippe Céruse^{4

8}, Pierre Philouze^{4

8}, Emmanuelle Uro-Coste⁹, Aurore Siegfried⁹, Valérie Costes-Martineau¹⁰, Anne Champagnac⁶, Nazim Benzerdjeb^{1

4

11}; REFCOR network

Collaborators, Affiliations

Collaborators

REFCOR network:
C Ala-Eddine, K Aubry, E Babin, C Bach, C Badoual, A C Baglin, B Barry, V Bastit, B Baujat, K Benezery, R J Bensadoun, N Benzerdjeb, M Bernadach, C Bertolus, A Biet, D Bodmer, P Boisselier, C Boulagnon-Rombi, L Bozec, A Bozorg Grayeli, E Brenet, L Brugel, G Calais, V Calugaru, S Camby, O Casiraghi, E Cassagnau, C Castain, J Castelli, P Ceruse, F Chabolle, D Chevalier, O Choussy, F Clatot, J M Constans, A Coste, F Coste, V Costes, J P Cottier, A Coutte, J P Cristofari, D Cupissol, J Delgrande, J P Delord, B Devauchelle, L Digue, G Dolivet, M Doré, S Duflo, X Dufour, C Dupin, E Eker, C Even, C Evrard, E Fabiano, S Faivre, N Fakhry, F R Ferrand, J Frandon, D Franetti, L de Gabory, C Galy, M Garcier, R Garrel, H Gauthier, L Gilain, S Guihard, S Guillerm, C Halimi, S Hans, P Herman, A Houessinon, M Hourseau, F Huguet, E Jadaud, R Jankowski, C Jeanne, F Jegoux, M Juliéron, R Kaci, M-C Kaminsky, H de Kermadec, F Kolb, S Kreps, M Laadhari, J Lacau Saint Guily, L Laccoureye, M Lae, F Lagarde, A Lagrange, B Lallemant, M Lamuraglia, P Lang, M Lapeyre, A Lapierre, A Lasne Cardon, C Le Tourneau, G Lefebvre, M Lefevre, Y Lelonge, X Leroy, M Lesnik, X Liem, C Linassier, P Maingon, C Majoufre, O Malard, G Malouf, C Marchand, J-P Marie, T Maurina, O Mauvais, J-C Merol, J Michel, G Mineur, S Mirafzal, H Mirghani, A Modesto, S Molinier-Blossier, E de Monès, S Morinière, F Mouawad, A Moya-Plana, L Muller, E Musat, F Nguyen, G Noel, F R Obongo-Anga, M Onea, H Orliac, C Page, V Patron, J Pestre, N Pham Dang, P Philouze, G Poissonnet, C Pons, C Pouliquen, J-M Prades, A Prevost, C Queiros, A Rahmani, A Rambeau, L Ramin, S Renard, A Siegfried, C A Righini, F Rolland, E Saada, F Sacino, S Salas, N Saroul, P Schultz, A Siegfried, A Simonaggio, O Sterkers, V Strunski, A Sudaka, S Xu-Shan, R Taouachi, M Tassart, S Testelin, J Thariat, M Timar David, A Timochenko, B Toussaint, E Uro Coste, G Valette, T Van den Abbele, A Varoquaux, E Vauleon, S Vergez, B Verillaud, J Villa, A Villepelet, M Volondat, N Vulquin, I Wagner, M Wassef, L Webert, S Wong

Affiliations

¹ Department of Pathology, Institut of Pathologie Multisite, Hospices Civils de Lyon, University South Lyon Hospital, Pierre-Bénite, France.
² Department of Pathology, CHU Nantes, Nantes, France.
³ Department of Oto-Rhino-Laryngology and Head and Neck Surgery, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Pierre-Bénite, France.
⁴ University Claude Bernard Lyon 1, Lyon, France.
⁵ Biochemistry and Molecular Biology Department, Hospices Civils de Lyon, University South Lyon Hospital, Pierre-Bénite, France.
⁶ Biopathology department, Centre Leon Berard, Lyon, France.
⁷ Team Genetics, Epigenetics and Biology of Sarcomas, INSERM 1052, CNRS 5286 of Cancer Research Center of Lyon, and Université Claude Bernard Lyon 1, Lyon, France.
⁸ Department of Oto-Rhino-Laryngology and Head and Neck Surgery, Hospices Civils de Lyon, La Croix Rousse Hospital, Lyon, France.
⁹ Department of Pathology, Institut Universitaire du Cancer-Oncopole, Toulouse, France.
¹⁰ Pathology Department, University Hospital of Montpellier, Montpellier, France.
¹¹ EMR3738, CICLY, Pierre-Bénite, France.

PMID: 39648963
DOI: 10.1111/his.15392

Case Reports

Understanding and overcoming the pitfalls in the diagnosis of pleomorphic and carcinoma ex-pleomorphic adenoma of salivary glands

Ziyad Alsugair et al. Histopathology. 2025 May.

. 2025 May;86(6):1013-1016.

doi: 10.1111/his.15392. Epub 2024 Dec 9.

Authors

Collaborators

REFCOR network:
C Ala-Eddine, K Aubry, E Babin, C Bach, C Badoual, A C Baglin, B Barry, V Bastit, B Baujat, K Benezery, R J Bensadoun, N Benzerdjeb, M Bernadach, C Bertolus, A Biet, D Bodmer, P Boisselier, C Boulagnon-Rombi, L Bozec, A Bozorg Grayeli, E Brenet, L Brugel, G Calais, V Calugaru, S Camby, O Casiraghi, E Cassagnau, C Castain, J Castelli, P Ceruse, F Chabolle, D Chevalier, O Choussy, F Clatot, J M Constans, A Coste, F Coste, V Costes, J P Cottier, A Coutte, J P Cristofari, D Cupissol, J Delgrande, J P Delord, B Devauchelle, L Digue, G Dolivet, M Doré, S Duflo, X Dufour, C Dupin, E Eker, C Even, C Evrard, E Fabiano, S Faivre, N Fakhry, F R Ferrand, J Frandon, D Franetti, L de Gabory, C Galy, M Garcier, R Garrel, H Gauthier, L Gilain, S Guihard, S Guillerm, C Halimi, S Hans, P Herman, A Houessinon, M Hourseau, F Huguet, E Jadaud, R Jankowski, C Jeanne, F Jegoux, M Juliéron, R Kaci, M-C Kaminsky, H de Kermadec, F Kolb, S Kreps, M Laadhari, J Lacau Saint Guily, L Laccoureye, M Lae, F Lagarde, A Lagrange, B Lallemant, M Lamuraglia, P Lang, M Lapeyre, A Lapierre, A Lasne Cardon, C Le Tourneau, G Lefebvre, M Lefevre, Y Lelonge, X Leroy, M Lesnik, X Liem, C Linassier, P Maingon, C Majoufre, O Malard, G Malouf, C Marchand, J-P Marie, T Maurina, O Mauvais, J-C Merol, J Michel, G Mineur, S Mirafzal, H Mirghani, A Modesto, S Molinier-Blossier, E de Monès, S Morinière, F Mouawad, A Moya-Plana, L Muller, E Musat, F Nguyen, G Noel, F R Obongo-Anga, M Onea, H Orliac, C Page, V Patron, J Pestre, N Pham Dang, P Philouze, G Poissonnet, C Pons, C Pouliquen, J-M Prades, A Prevost, C Queiros, A Rahmani, A Rambeau, L Ramin, S Renard, A Siegfried, C A Righini, F Rolland, E Saada, F Sacino, S Salas, N Saroul, P Schultz, A Siegfried, A Simonaggio, O Sterkers, V Strunski, A Sudaka, S Xu-Shan, R Taouachi, M Tassart, S Testelin, J Thariat, M Timar David, A Timochenko, B Toussaint, E Uro Coste, G Valette, T Van den Abbele, A Varoquaux, E Vauleon, S Vergez, B Verillaud, J Villa, A Villepelet, M Volondat, N Vulquin, I Wagner, M Wassef, L Webert, S Wong

Affiliations

¹ Department of Pathology, Institut of Pathologie Multisite, Hospices Civils de Lyon, University South Lyon Hospital, Pierre-Bénite, France.
² Department of Pathology, CHU Nantes, Nantes, France.
³ Department of Oto-Rhino-Laryngology and Head and Neck Surgery, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Pierre-Bénite, France.
⁴ University Claude Bernard Lyon 1, Lyon, France.
⁵ Biochemistry and Molecular Biology Department, Hospices Civils de Lyon, University South Lyon Hospital, Pierre-Bénite, France.
⁶ Biopathology department, Centre Leon Berard, Lyon, France.
⁷ Team Genetics, Epigenetics and Biology of Sarcomas, INSERM 1052, CNRS 5286 of Cancer Research Center of Lyon, and Université Claude Bernard Lyon 1, Lyon, France.
⁸ Department of Oto-Rhino-Laryngology and Head and Neck Surgery, Hospices Civils de Lyon, La Croix Rousse Hospital, Lyon, France.
⁹ Department of Pathology, Institut Universitaire du Cancer-Oncopole, Toulouse, France.
¹⁰ Pathology Department, University Hospital of Montpellier, Montpellier, France.
¹¹ EMR3738, CICLY, Pierre-Bénite, France.

PMID: 39648963
DOI: 10.1111/his.15392

Erratum in

Correction to "Understanding and overcoming the pitfalls in the diagnosis of pleomorphic and carcinoma ex-pleomorphic adenoma of salivary glands".
[No authors listed] [No authors listed] Histopathology. 2025 Jul;87(1):165. doi: 10.1111/his.15467. Epub 2025 May 7. Histopathology. 2025. PMID: 40342056 No abstract available.

Abstract

The study illustrates a recurrent pitfall in the diagnosis of pleomorphic adenoma and carcinoma ex pleomorphic adenoma.

Keywords: RNA sequencing; carcinoma ex‐pleomorphic adenoma; mucocytes; mucoepidermoid carcinoma; mucus secreting cells; pitfalls.

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Understanding and overcoming the pitfalls in the diagnosis of pleomorphic and carcinoma ex-pleomorphic adenoma of salivary glands

Collaborators

Affiliations

Understanding and overcoming the pitfalls in the diagnosis of pleomorphic and carcinoma ex-pleomorphic adenoma of salivary glands

Authors

Collaborators

Affiliations

Erratum in

Abstract

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical