First-Generation Anti-Obesity Medications
- PMID: 39649696
- PMCID: PMC11623038
- DOI: 10.2337/dsi24-0003
First-Generation Anti-Obesity Medications
Abstract
The development of second-generation anti-obesity medications (AOMs) has transformed the treatment of obesity. However, the first-generation AOMs are still essential tools in the treatment of obesity. The decision of which AOM to initiate must be individualized taking into account patient preference, safety, tolerability, cost, and supply.
© 2024 by the American Diabetes Association.
Conflict of interest statement
No potential conflicts of interest relevant to this article were reported.
References
-
- Apovian CM, Aronne LJ, Bessesen DH, et al.; Endocrine Society . Pharmacological management of obesity: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2015;100:342–362 - PubMed
-
- Garvey WT, Mechanick JI, Brett EM, et al.; Reviewers of the AACE/ACE Obesity Clinical Practice Guidelines . American Association of Clinical Endocrinologists and American College of Endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity. Endocr Pract 2016;22(Suppl. 3):1–203 - PubMed
-
- Roche Pharmaceuticals. Xenical [package insert] . Available from https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020766s026lbl.pdf. Accessed March 2024
-
- Torgerson JS, Hauptman J, Boldrin MN, Sjöström L.. XENical in the prevention of diabetes in obese subjects (XENDOS) study: a randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients. Diabetes Care 2004;27:155–161 - PubMed
LinkOut - more resources
Full Text Sources
