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. 2024 Nov 22:14:1453346.
doi: 10.3389/fonc.2024.1453346. eCollection 2024.

Correlation analysis of preoperative renal insufficiency with major complications in patients who received a radical cystectomy and pelvic lymph node dissection: results of a retrospective observational analysis from a single center

Haixin Wang #  1   2   3   4 , Haiwen Huang #  5 , Han Hao  1   2   3 , Zhijun Xi  1   2   3
Affiliations

Correlation analysis of preoperative renal insufficiency with major complications in patients who received a radical cystectomy and pelvic lymph node dissection: results of a retrospective observational analysis from a single center

Haixin Wang et al. Front Oncol. .

Abstract

Objective: The aim of this study was to explore the factors affecting the major complications and the impacts of preoperative renal function on the incidence of complications in radical cystectomy procedures.

Methods: A retrospective review of 705 patients who received radical cystectomy between 2006 and 2021 was conducted. The 90-day complications of patients after a radical cystectomy were reported and the Clavien-Dindo classification (CDC) was used for grading complications. The clinical characteristics and preoperative outcomes were compared among patients with different preoperative renal functions. A logistic regression analysis of all patients was used to identify the risk factors associated with the major complications. Spearman's correlation analysis was used to examine the relationship between the classification of renal insufficiency and the CDC. In order to reduce the selection bias, one-to-one propensity score matching was performed, and the comparison of complications after matching was carried out for the sensitivity analysis.

Results: Within 90 days post-surgery, 71% of patients experienced complications, with 4.8% of them being major. Patients with preoperative renal insufficiency had a higher CDC and had a higher rate of major complications (16.7% vs 3.7%, p < 0.001). There was a linear relationship between preoperative serum creatinine and complications. Spearman's correlation analysis showed a slightly positive correlation between the classification of renal insufficiency and the CDC (r=0.094, p = 0.013). Preoperative renal insufficiency was a risk factor for major complications (OR = 6.805 [95%CI: 2.706-17.112]; p < 0.001). After matching, the patients in the preoperative renal insufficiency group had a higher CDC and a higher incidence of major complications (16.9% vs 1.7%, p = 0.004).

Conclusions: In our cohort, patients with preoperative renal insufficiency exhibited a higher incidence of complications following a radical cystectomy, and renal insufficiency was a significant risk factor for major complications.

Keywords: Clavien-Dindo; complications; radical cystectomy; renal function; renal insufficiency.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of all eligible patients. PLND, pelvic lymph node dissection.
See this image and copyright information in PMC

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References

    1. Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA: A Cancer J Clin. (2022) 72:7–33. doi: 10.3322/caac.21708 - DOI - PubMed
    1. Witjes JA, Bruins HM, Cathomas R, Compérat E, Cowan NC, Efstathiou JA, et al. . EAU guidelines on muscle invasive and metastatic bladder cancer. EAU Guidelines. (2021). doi: 10.1016/j.eururo.2020.03.055 - DOI
    1. Hautmann RE, de Petriconi RC, Volkmer BG. Lessons learned from 1,000 neobladders: the 90-day complication rate. J Urol. (2010) 184:990–4; quiz 1235. doi: 10.1016/j.juro.2010.05.037 - DOI - PubMed
    1. Johnson SC, Smith ZL, Golan S, Rodriguez JF, 3rd, Smith ND, Steinberg GD. Temporal trends in perioperative morbidity for radical cystectomy using the National Surgical Quality Improvement Program database. Urologic Oncol. (2017) 35:659.e13–.e19. doi: 10.1016/j.urolonc.2017.07.013 - DOI - PubMed
    1. Morgan TM, Keegan KA, Barocas DA, Ruhotina N, Phillips SE, Chang SS, et al. . Predicting the probability of 90-day survival of elderly patients with bladder cancer treated with radical cystectomy. J Urol. (2011) 186:829–34. doi: 10.1016/j.juro.2011.04.089 - DOI - PMC - PubMed

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