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Case Reports
. 2024 Nov 7;16(11):e73219.
doi: 10.7759/cureus.73219. eCollection 2024 Nov.

Navigating the Complexity of Stiff Person Syndrome: A Case Report and Literature Review

Jordyn Mullins  1 , Cody Sheppard  1 , Brian R Beyer  1 , Cheri Blacksten  1
Affiliations
Case Reports

Navigating the Complexity of Stiff Person Syndrome: A Case Report and Literature Review

Jordyn Mullins et al. Cureus. .

Abstract

Stiff person spectrum disorder is a disease that involves a host of conditions that are associated with glutamic acid decarboxylase 65-kilodalton isoform autoantibodies. These conditions may include diabetes mellitus type 1, pernicious anemia, autoimmune leukoencephalopathy, cerebellar ataxia, and stiff-person syndrome. Clinical recognition and diagnosis of stiff person spectrum disorder are important early, as immunologic treatment options showing reliable efficacy in slowing disease progression are available. This case presents a wide constellation of symptoms in which we describe the pathophysiology, clinical diagnosis, and current as well as future treatment options that may be available. .

Keywords: gad65; pernicious anaemia; stiff person syndrome; stiff-person syndrome; type i diabetes mellitus.

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Conflict of interest statement

Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

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