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. 2024 Nov 6;10(11):1976-1979.
doi: 10.1021/acscentsci.4c01803. eCollection 2024 Nov 27.

The Fight Against Frostbite Progresses

Ute Eberle

The Fight Against Frostbite Progresses

Ute Eberle. ACS Cent Sci. .
No abstract available

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Figures

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The Montane Yukon Arctic Ultra is a multiday race in which athletes run, bike, or ski long distances through a bitterly cold environment. Alexander Poole gained special permission to use iloprost for frostbite in 2015, before that year’s race. Photos are from the 2023 race. Credit: Mark Kelly
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To create iloprost chemists started with prostacyclin—a hormone that occurs naturally in the body—and replaced the oxygen atom in its enol ether with a carbon. They also added an alkyne and a methyl substituent to one of the new compound’s side chains.
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A Montane Yukon Arctic Ultra runner's hand after he was evacuated from the race. Surgeon Alexander Poole and colleagues treated him with iloprost for 5 days. Photos A and B show the hand on day 1 and day 2, respectively, of his hospital stay. Photo C is 1 month after treatment, and Photo D is 6 months after treatment. Credit: Can. Med. Assoc. J., DOI: 10.1503/cmaj.151252
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