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Review
. 2025 Jan 1;53(1):41-47.
doi: 10.1249/JES.0000000000000352. Epub 2024 Nov 4.

Task-Dependent Mechanisms Underlying Prolonged Low-Frequency Force Depression

Andrew J Richards  1 , Daiki Watanabe  2 , Takashi Yamada  3 , Håkan Westerblad  4 , Arthur J Cheng  1
Affiliations
Review

Task-Dependent Mechanisms Underlying Prolonged Low-Frequency Force Depression

Andrew J Richards et al. Exerc Sport Sci Rev. .

Abstract

Prolonged low-frequency force depression (PLFFD) is an intramuscular phenomenon involving the slow recovery of submaximal muscle strength following strenuous exercise. We hypothesize that the contribution of impaired excitation-contraction coupling processes to PLFFD is task dependent, and that they will be different between metabolically and mechanically demanding exercises. We also discuss evidence of the effectiveness of interventions to mitigate PLFFD.

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References

    1. Edwards RH, Hill DK, Jones DA, Merton PA. Fatigue of long duration in human skeletal muscle after exercise. J. Physiol. 1977; 272:769–78.
    1. Grimby L, Hannerz J. Firing rate and recruitment order of toe extensor motor units in different modes of voluntary conraction. J. Physiol. 1977; 264:865–79.
    1. Bruton JD, Place N, Yamada T, et al. Reactive oxygen species and fatigue-induced prolonged low-frequency force depression in skeletal muscle fibres of rats, mice and SOD2 overexpressing mice. J. Physiol. 2008; 586:175–84.
    1. Cheng AJ, Yamada T, Rassier DE, Andersson DC, Westerblad H, Lanner JT. Reactive oxygen/nitrogen species and contractile function in skeletal muscle during fatigue and recovery. J. Physiol. 2016; 594:5149–60.
    1. Olsson K, Cheng AJ, Al-Ameri M, et al. Impaired sarcoplasmic reticulum Ca2+ release is the major cause of fatigue-induced force loss in intact single fibres from human intercostal muscle. J. Physiol. 2020; 598:773–87.

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