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. 2025 Mar;46(3):1379-1381.
doi: 10.1007/s10072-024-07910-0. Epub 2024 Dec 9.

RAB32 Ser71Arg in Chinese patients with Parkinson's disease

Yinge Xue  1 , Minglei Liu  1 , Kaixin Chen  1 , Yuming Xu  1 , Jing Yang  2
Affiliations

RAB32 Ser71Arg in Chinese patients with Parkinson's disease

Yinge Xue et al. Neurol Sci. 2025 Mar.

Abstract

Background: The RAB32 Ser71Arg variant has been identified as a novel risk locus for Parkinson's disease (PD) in North American, European and North African populations. However, its pathogenicity in Asian populations remains unclear.

Method: To investigate this, we screened for the RAB32 c.213C > G (Ser71Arg) variant using Sanger sequencing in 1,099 PD patients and 1,549 controls. And we search for the RAB32 Ser71Arg variant in public databases to identified its mutant frequency.

Results: Our results show that no individuals carrying the RAB32 Ser71Arg variant were identified in our cohort. Additionally, this variant rarely appears in Asian population databases.

Conclusion: Our findings suggest that the RAB32 Ser71Arg variant is unlikely to be a risk locus for PD in Chinese patients, which is potentially attributed to racial or ethnic differences.

Keywords: Chinese populations; Genetics; Parkinson’s disease; RAB32.

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Conflict of interest statement

Declarations. Ethical compliance statement: The study was approved by the ethics committee of the First Affiliated Hospital of Zhengzhou University (No.2019-KY-294). Conflict of interest: We declare no competing interests. Informed consent: Written informed consent was obtained from all study participants before enrollment.

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