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Review
. 2024 Dec 5:17:41-58.
doi: 10.2147/SCCAA.S481072. eCollection 2024.

Advancements in Umbilical Cord Biobanking: A Comprehensive Review of Current Trends and Future Prospects

Sahar AlOraibi  1 , Sebastien Taurin  1 , Sfoug Alshammary  1
Affiliations
Review

Advancements in Umbilical Cord Biobanking: A Comprehensive Review of Current Trends and Future Prospects

Sahar AlOraibi et al. Stem Cells Cloning. .

Abstract

Biobanking has emerged as a transformative concept in advancing the medical field, particularly with the exponential growth of umbilical cord (UC) biobanking in recent decades. UC blood and tissue provide a rich source of primitive hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) for clinical transplantation, offering distinct advantages over alternative adult stem cell sources. However, to fully realize the therapeutic potential of UC-derived stem cells and establish a comprehensive global UC-biobanking network, it is imperative to optimize and standardize UC processing, cryopreservation methods, quality control protocols, and regulatory frameworks, alongside developing effective consent provisions. This review aims to comprehensively explore recent advancements in UC biobanking, focusing on the establishment of rigorous safety and quality control procedures, the standardization of biobanking operations, and the optimization and automation of UC processing and cryopreservation techniques. Additionally, the review examines the expanded clinical applications of UC stem cells, addresses the challenges associated with umbilical cord biobanking and UC-derived stem cell therapies, and discusses the promising role of artificial intelligence (AI) in enhancing various operational aspects of biobanking, streamlining data processing, and improving data analysis accuracy while ensuring compliance with safety and quality standards. By addressing these critical areas, this review seeks to provide insights into the future direction of UC biobanking and its potential to significantly impact regenerative medicine.

Keywords: artificial intelligence; cryopreservation; hematopoietic stem cells; mesenchymal stem cells; umbilical cord biobanking.

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Conflict of interest statement

We declare there is no conflict of interest.

Figures

Figure 1
Figure 1
Proportion of the clinical conditions investigating umbilical cord-derived mesenchymal stem cell therapy: Data was sourced from ClinicalTrials.gov, spanning August 2013 to September 2023.
See this image and copyright information in PMC

References

    1. Knoppers BM, Isasi R. Stem cell banking: between traceability and identifiability. Genome Med. 2010;2:73. doi:10.1186/gm194 - DOI - PMC - PubMed
    1. Annaratone L, De Palma G, Bonizzi G, et al. Basic principles of biobanking: from biological samples to precision medicine for patients. Virchows Archiv. 2021;479(2):233–246. doi:10.1007/s00428-021-03151-0 - DOI - PMC - PubMed
    1. Ballen KK, Verter F, Kurtzberg J. Umbilical cord blood donation: public or private? Bone Marrow Transplant. 2015;50:1271–1278. doi:10.1038/bmt.2015.124 - DOI - PubMed
    1. Butler MG, Menitove JE. Umbilical cord blood banking: an update. J Assist Reprod Genet. 2011;28:669–676. doi:10.1007/s10815-011-9577-x - DOI - PMC - PubMed
    1. Brunstein CG, Wagner JE. Umbilical cord blood transplantation and banking. Annu Rev Med. 2006;57:403–417. doi:10.1146/annurev.med.57.051804.123642 - DOI - PubMed

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